Nature Communications (Dec 2021)
Induction of Rosette-to-Lumen stage embryoids using reprogramming paradigms in ESCs
- Jan Langkabel,
- Arik Horne,
- Lorenzo Bonaguro,
- Lisa Holsten,
- Tatiana Hesse,
- Alexej Knaus,
- Yannick Riedel,
- Matthias Becker,
- Kristian Händler,
- Tarek Elmzzahi,
- Kevin Bassler,
- Nico Reusch,
- Leon Harootoonovtch Yeghiazarian,
- Tal Pecht,
- Adem Saglam,
- Thomas Ulas,
- Anna C. Aschenbrenner,
- Franziska Kaiser,
- Caroline Kubaczka,
- Joachim L. Schultze,
- Hubert Schorle
Affiliations
- Jan Langkabel
- Institute of Pathology, Department of Developmental Pathology, University Hospital Bonn, University of Bonn
- Arik Horne
- Genomics and Immunoregulation, Life and Medical Sciences (LIMES) Institute, University of Bonn
- Lorenzo Bonaguro
- Genomics and Immunoregulation, Life and Medical Sciences (LIMES) Institute, University of Bonn
- Lisa Holsten
- Genomics and Immunoregulation, Life and Medical Sciences (LIMES) Institute, University of Bonn
- Tatiana Hesse
- Institute of Pathology, Department of Developmental Pathology, University Hospital Bonn, University of Bonn
- Alexej Knaus
- Institute of Pathology, Department of Developmental Pathology, University Hospital Bonn, University of Bonn
- Yannick Riedel
- Institute of Pathology, Department of Developmental Pathology, University Hospital Bonn, University of Bonn
- Matthias Becker
- Systems Medicine, DZNE, Bonn, Germany and University of Bonn
- Kristian Händler
- Genomics and Immunoregulation, Life and Medical Sciences (LIMES) Institute, University of Bonn
- Tarek Elmzzahi
- Molecular Immunology in Neurodegeneration, DZNE
- Kevin Bassler
- Genomics and Immunoregulation, Life and Medical Sciences (LIMES) Institute, University of Bonn
- Nico Reusch
- Genomics and Immunoregulation, Life and Medical Sciences (LIMES) Institute, University of Bonn
- Leon Harootoonovtch Yeghiazarian
- Genomics and Immunoregulation, Life and Medical Sciences (LIMES) Institute, University of Bonn
- Tal Pecht
- Genomics and Immunoregulation, Life and Medical Sciences (LIMES) Institute, University of Bonn
- Adem Saglam
- Systems Medicine, DZNE, Bonn, Germany and University of Bonn
- Thomas Ulas
- Genomics and Immunoregulation, Life and Medical Sciences (LIMES) Institute, University of Bonn
- Anna C. Aschenbrenner
- Genomics and Immunoregulation, Life and Medical Sciences (LIMES) Institute, University of Bonn
- Franziska Kaiser
- Institute of Pathology, Department of Developmental Pathology, University Hospital Bonn, University of Bonn
- Caroline Kubaczka
- Institute of Pathology, Department of Developmental Pathology, University Hospital Bonn, University of Bonn
- Joachim L. Schultze
- Genomics and Immunoregulation, Life and Medical Sciences (LIMES) Institute, University of Bonn
- Hubert Schorle
- Institute of Pathology, Department of Developmental Pathology, University Hospital Bonn, University of Bonn
- DOI
- https://doi.org/10.1038/s41467-021-27586-w
- Journal volume & issue
-
Vol. 12,
no. 1
pp. 1 – 18
Abstract
Synthetic embryo models have arisen as an approach to probe early development in vitro, facilitating the study of difficult to access stages. Here the authors present a simple system for generating embryo-like structures that resemble peri-implantation mouse embryos.
