Nature Communications (Mar 2021)
Deciphering the state of immune silence in fatal COVID-19 patients
- Pierre Bost,
- Francesco De Sanctis,
- Stefania Canè,
- Stefano Ugel,
- Katia Donadello,
- Monica Castellucci,
- David Eyal,
- Alessandra Fiore,
- Cristina Anselmi,
- Roza Maria Barouni,
- Rosalinda Trovato,
- Simone Caligola,
- Alessia Lamolinara,
- Manuela Iezzi,
- Federica Facciotti,
- Annarita Mazzariol,
- Davide Gibellini,
- Pasquale De Nardo,
- Evelina Tacconelli,
- Leonardo Gottin,
- Enrico Polati,
- Benno Schwikowski,
- Ido Amit,
- Vincenzo Bronte
Affiliations
- Pierre Bost
- Department of Immunology, Weizmann Institute of Science
- Francesco De Sanctis
- Immunology Section, Department of Medicine, University and Hospital Trust of Verona
- Stefania Canè
- Immunology Section, Department of Medicine, University and Hospital Trust of Verona
- Stefano Ugel
- Immunology Section, Department of Medicine, University and Hospital Trust of Verona
- Katia Donadello
- Intensive Care Unit, Department of Surgery, Dentistry, Maternity and Infant, University and Hospital Trust of Verona
- Monica Castellucci
- The Center for Technological Platforms, University of Verona
- David Eyal
- Department of Immunology, Weizmann Institute of Science
- Alessandra Fiore
- Immunology Section, Department of Medicine, University and Hospital Trust of Verona
- Cristina Anselmi
- Immunology Section, Department of Medicine, University and Hospital Trust of Verona
- Roza Maria Barouni
- Immunology Section, Department of Medicine, University and Hospital Trust of Verona
- Rosalinda Trovato
- Immunology Section, Department of Medicine, University and Hospital Trust of Verona
- Simone Caligola
- Immunology Section, Department of Medicine, University and Hospital Trust of Verona
- Alessia Lamolinara
- CAST- Center for Advanced Studies and Technology, Department of Neurosciences, Imaging and Clinical Sciences, University of G. D’Annunzio of Chieti-Pescara
- Manuela Iezzi
- CAST- Center for Advanced Studies and Technology, Department of Neurosciences, Imaging and Clinical Sciences, University of G. D’Annunzio of Chieti-Pescara
- Federica Facciotti
- Department of Experimental Oncology, IEO European Institute of Oncology IRCCS
- Annarita Mazzariol
- Microbiology Unit, Department of Diagnostics and Public Health, University and Hospital Trust of Verona
- Davide Gibellini
- Microbiology Unit, Department of Diagnostics and Public Health, University and Hospital Trust of Verona
- Pasquale De Nardo
- Division of Infectious Diseases, Department of Diagnostics and Public Health, University and Hospital Trust of Verona
- Evelina Tacconelli
- Division of Infectious Diseases, Department of Diagnostics and Public Health, University and Hospital Trust of Verona
- Leonardo Gottin
- Intensive Care Unit, Department of Surgery, Dentistry, Maternity and Infant, University and Hospital Trust of Verona
- Enrico Polati
- Intensive Care Unit, Department of Surgery, Dentistry, Maternity and Infant, University and Hospital Trust of Verona
- Benno Schwikowski
- Systems Biology Group, Department of Computational Biology and USR 3756, Institut Pasteur and CNRS
- Ido Amit
- Department of Immunology, Weizmann Institute of Science
- Vincenzo Bronte
- Immunology Section, Department of Medicine, University and Hospital Trust of Verona
- DOI
- https://doi.org/10.1038/s41467-021-21702-6
- Journal volume & issue
-
Vol. 12,
no. 1
pp. 1 – 15
Abstract
Integrated studies of matched tissue sites and cell types in COVID-19 patients are important to define the immune mechanisms of pathology. Here, the authors describe an immune signature in fatal COVID-19 patients harmonizing single-cell RNA sequencing of blood and matched BAL cells with deep clinical, immunological and functional data.
