Nature Communications (Apr 2016)

Genetically encoded photocrosslinkers locate the high-affinity binding site of antidepressant drugs in the human serotonin transporter

  • Hafsteinn Rannversson,
  • Jacob Andersen,
  • Lena Sørensen,
  • Benny Bang-Andersen,
  • Minyoung Park,
  • Thomas Huber,
  • Thomas P. Sakmar,
  • Kristian Strømgaard

DOI
https://doi.org/10.1038/ncomms11261
Journal volume & issue
Vol. 7, no. 1
pp. 1 – 9

Abstract

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Molecular details of how antidepressant drugs bind to the human serotonin transporter are not currently clear. Here, the authors introduce photo-cross-linkers into the protein and map the binding site of several antidepressants.