Clinical management of patients with diseases of the cervix with persistent HPV infection: the possibility of combined treatment

Abstract

Understanding the persistence of HPV infection in cervical epithelium and associated development of benign diseases defines the tactics and treatment of cervical lesions associated with HPV.The Aim. To study the efficacy and long-term results of treating the benign cervical disease with persistent HPV infection when using the drug in combina-tion with Isoprinosine surgically.Material and methods: 80 patients with persistent HPV infection and cervical diseases. Combination therapy included: antiviral treatment of HPV infection (inosine pranobex) treatment aimed at the elimination of concomitant opportunistic microflora, yeasts and other microorganisms, radio frequency destruction, restoration of vaginal biocenosis. Determining factor in the choice of surgical intervention were the following factors: cytological and colposcopic data research methods; the presence or absence of a pathological process involving the cervical canal.The Results. Combination antiviral therapy in conjunction with radio wave surgery of benign cervical disease shows patients with persistent HPV infecion, have LSIL and HSIL, quantitative test positive for HPV, and had undergone previous surgical treatment of cervical other methods.

Keywords

• mild dysplasia
• intraepithelial neoplasia i degree (cin i)
• low-grade intraepithelial lesions (lsil)
• inosine pranobex
• radiowave surgery
• isoprinosine