Nature Communications (Oct 2019)

N6-methyladenosine mRNA marking promotes selective translation of regulons required for human erythropoiesis

  • Daniel A. Kuppers,
  • Sonali Arora,
  • Yiting Lim,
  • Andrea R. Lim,
  • Lucas M. Carter,
  • Philip D. Corrin,
  • Christopher L. Plaisier,
  • Ryan Basom,
  • Jeffrey J. Delrow,
  • Shiyan Wang,
  • Housheng Hansen He,
  • Beverly Torok-Storb,
  • Andrew C. Hsieh,
  • Patrick J. Paddison

DOI
https://doi.org/10.1038/s41467-019-12518-6
Journal volume & issue
Vol. 10, no. 1
pp. 1 – 17

Abstract

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Erythropoiesis can be regulated by transcriptional, epigenetic, and post-transcriptional mechanisms. Here the authors report that N6-methyladenosine mRNA methyltransferase complex stimulates erythropoiesis by promoting translation of specific mRNAs.