Nature Communications (Oct 2018)
APOE ε2 is associated with increased tau pathology in primary tauopathy
- Na Zhao,
- Chia-Chen Liu,
- Alexandra J. Van Ingelgom,
- Cynthia Linares,
- Aishe Kurti,
- Joshua A. Knight,
- Michael G. Heckman,
- Nancy N. Diehl,
- Mitsuru Shinohara,
- Yuka A. Martens,
- Olivia N. Attrebi,
- Leonard Petrucelli,
- John D. Fryer,
- Zbigniew K. Wszolek,
- Neill R. Graff-Radford,
- Richard J. Caselli,
- Monica Y. Sanchez-Contreras,
- Rosa Rademakers,
- Melissa E. Murray,
- Shunsuke Koga,
- Dennis W. Dickson,
- Owen A. Ross,
- Guojun Bu
Affiliations
- Na Zhao
- Department of Neuroscience, Mayo Clinic
- Chia-Chen Liu
- Department of Neuroscience, Mayo Clinic
- Alexandra J. Van Ingelgom
- Department of Neuroscience, Mayo Clinic
- Cynthia Linares
- Department of Neuroscience, Mayo Clinic
- Aishe Kurti
- Department of Neuroscience, Mayo Clinic
- Joshua A. Knight
- Department of Neuroscience, Mayo Clinic
- Michael G. Heckman
- Division of Biomedical Statistics and Informatics, Mayo Clinic
- Nancy N. Diehl
- Division of Biomedical Statistics and Informatics, Mayo Clinic
- Mitsuru Shinohara
- Department of Neuroscience, Mayo Clinic
- Yuka A. Martens
- Department of Neuroscience, Mayo Clinic
- Olivia N. Attrebi
- Department of Neuroscience, Mayo Clinic
- Leonard Petrucelli
- Department of Neuroscience, Mayo Clinic
- John D. Fryer
- Department of Neuroscience, Mayo Clinic
- Zbigniew K. Wszolek
- Department of Neurology, Mayo Clinic
- Neill R. Graff-Radford
- Department of Neurology, Mayo Clinic
- Richard J. Caselli
- Department of Neurology, Mayo Clinic
- Monica Y. Sanchez-Contreras
- Department of Neuroscience, Mayo Clinic
- Rosa Rademakers
- Department of Neuroscience, Mayo Clinic
- Melissa E. Murray
- Department of Neuroscience, Mayo Clinic
- Shunsuke Koga
- Department of Neuroscience, Mayo Clinic
- Dennis W. Dickson
- Department of Neuroscience, Mayo Clinic
- Owen A. Ross
- Department of Neuroscience, Mayo Clinic
- Guojun Bu
- Department of Neuroscience, Mayo Clinic
- DOI
- https://doi.org/10.1038/s41467-018-06783-0
- Journal volume & issue
-
Vol. 9,
no. 1
pp. 1 – 11
Abstract
The APOE ε4 allele is a strong genetic risk factor for Alzheimer’s disease, whereas the APOE ε2 allele is protective. Here the authors show that mice expressing the human APOE ε2/ε2 genotype have increased tau pathology and related behavioral deficits; they also find that the APOE ε2 allele is associated with an increased burden of tau pathology in postmortem human brains with progressive supranuclear palsy.
