A synthetic lethal screen identifies HDAC4 as a potential target in MELK overexpressing cancers

Lin Zhou; Siqi Zheng; Fernando R Rosas Bringas; Bjorn Bakker; Judith E Simon; Petra L Bakker; Hinke G Kazemier; Michael Schubert; Maurits Roorda; Marcel A T M van Vugt; Michael Chang; Floris Foijer

doi:10.1093/g3journal/jkab335

G3: Genes, Genomes, Genetics (Sep 2021)

A synthetic lethal screen identifies HDAC4 as a potential target in MELK overexpressing cancers

Lin Zhou,
Siqi Zheng,
Fernando R Rosas Bringas,
Bjorn Bakker,
Judith E Simon,
Petra L Bakker,
Hinke G Kazemier,
Michael Schubert,
Maurits Roorda,
Marcel A T M van Vugt,
Michael Chang,
Floris Foijer

Affiliations

Lin Zhou: European Research Institute for the Biology of Ageing, University of Groningen, University Medical Center Groningen, Groningen 9713 AV, The Netherlands
Siqi Zheng: European Research Institute for the Biology of Ageing, University of Groningen, University Medical Center Groningen, Groningen 9713 AV, The Netherlands
Fernando R Rosas Bringas: ORCiD; European Research Institute for the Biology of Ageing, University of Groningen, University Medical Center Groningen, Groningen 9713 AV, The Netherlands
Bjorn Bakker: European Research Institute for the Biology of Ageing, University of Groningen, University Medical Center Groningen, Groningen 9713 AV, The Netherlands
Judith E Simon: European Research Institute for the Biology of Ageing, University of Groningen, University Medical Center Groningen, Groningen 9713 AV, The Netherlands
Petra L Bakker: European Research Institute for the Biology of Ageing, University of Groningen, University Medical Center Groningen, Groningen 9713 AV, The Netherlands
Hinke G Kazemier: European Research Institute for the Biology of Ageing, University of Groningen, University Medical Center Groningen, Groningen 9713 AV, The Netherlands
Michael Schubert: European Research Institute for the Biology of Ageing, University of Groningen, University Medical Center Groningen, Groningen 9713 AV, The Netherlands
Maurits Roorda: ORCiD; Department of Medical Oncology, University of Groningen, University Medical Center Groningen, Groningen 9713 AV, The Netherlands
Marcel A T M van Vugt: Department of Medical Oncology, University of Groningen, University Medical Center Groningen, Groningen 9713 AV, The Netherlands
Michael Chang: ORCiD; European Research Institute for the Biology of Ageing, University of Groningen, University Medical Center Groningen, Groningen 9713 AV, The Netherlands
Floris Foijer: ORCiD; European Research Institute for the Biology of Ageing, University of Groningen, University Medical Center Groningen, Groningen 9713 AV, The Netherlands

DOI: https://doi.org/10.1093/g3journal/jkab335
Journal volume & issue: Vol. 11, no. 12

Abstract

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AbstractMaternal embryonic leucine zipper kinase (MELK) is frequently overexpressed in cancer, but the role of MELK in cancer is still poorly understood. MELK was shown to have roles in many cancer-associated processes including tumor growth, chemotherapy resistance, and tumor recurrence. To determine whether the frequent overexpression of MELK can be exploited in therapy, we performed a high-throughput screen using a library of Saccharomyces cerevisiaeLAG2HDA3LAG2HDA3HDA1HDA3

Published in G3: Genes, Genomes, Genetics

ISSN: 2160-1836 (Online)
Publisher: Oxford University Press
Country of publisher: United Kingdom
LCC subjects: Science: Biology (General): Genetics
Website: https://academic.oup.com/g3journal

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