Selected 3-hydroxy-3-methyl-glutaryl-coenzyme A reductase inhibitors. A look into their use and potential in pre-diabetes and type 2 diabetes

Abstract

Objectives. This review assesses the comparative safety and efficacy of selected 3-hydroxy-3-methylglutaric acid coenzyme A inhibitors (statins, cinnamic acids. 3-hydroxy-3-methyl glutaric acid) on the pre-onset type 2 diabetes (PT2D) and post-onset type 2 diabetes (T2D)-related cluster of seven features (central obesity, hyperglycemia, hypertension, dyslipidemia, pro-thrombosis, oxidation and inflammation).

Keywords

• statins
• flaxseed lignan complex
• cinnamic acids
• 3-hydroxy-3-methylglutaric acid
• 3-hydroxy-3-methylglutaric acid coenzyme a reductase inhibition
• type 2 diabetes mellitus
• central obesity
• hyperglycemia
• hypertension
• dyslipidemia
• pro-thrombosis
• oxidation and inflammation