Structural basis of myelin-associated glycoprotein adhesion and signalling

Matti F. Pronker; Suzanne Lemstra; Joost Snijder; Albert J. R. Heck; Dominique M. E. Thies-Weesie; R. Jeroen Pasterkamp; Bert J. C. Janssen

doi:10.1038/ncomms13584

Nature Communications (Dec 2016)

Structural basis of myelin-associated glycoprotein adhesion and signalling

Matti F. Pronker,
Suzanne Lemstra,
Joost Snijder,
Albert J. R. Heck,
Dominique M. E. Thies-Weesie,
R. Jeroen Pasterkamp,
Bert J. C. Janssen

Affiliations

Matti F. Pronker: Department of Chemistry, Crystal and Structural Chemistry, Bijvoet Center for Biomolecular Research, Faculty of Science, Utrecht University
Suzanne Lemstra: Department for Translational Neuroscience, Brain Center Rudolf Magnus, University Medical Center Utrecht, Universiteitsweg 100
Joost Snijder: Department of Chemistry and Department of Pharmaceutical Sciences, Biomolecular Mass Spectrometry and Proteomics, Bijvoet Center for Biomolecular Research and Utrecht Institute for Pharmaceutical Sciences, Faculty of Science, Utrecht University
Albert J. R. Heck: Department of Chemistry and Department of Pharmaceutical Sciences, Biomolecular Mass Spectrometry and Proteomics, Bijvoet Center for Biomolecular Research and Utrecht Institute for Pharmaceutical Sciences, Faculty of Science, Utrecht University
Dominique M. E. Thies-Weesie: Department of Chemistry, Van’t Hoff Laboratory for Physical and Colloid Chemistry, Debye Institute of Nanomaterials Science, Faculty of Science, Utrecht University
R. Jeroen Pasterkamp: Department for Translational Neuroscience, Brain Center Rudolf Magnus, University Medical Center Utrecht, Universiteitsweg 100
Bert J. C. Janssen: Department of Chemistry, Crystal and Structural Chemistry, Bijvoet Center for Biomolecular Research, Faculty of Science, Utrecht University

DOI: https://doi.org/10.1038/ncomms13584
Journal volume & issue: Vol. 7, no. 1
pp. 1 – 13

Abstract

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Myelin-associated glycoprotein (MAG) maintains myelin-axon spacing. Here, the authors report the crystal structures of the MAG full ectodomain in complex with oligosaccharide, and use additional assays to provide insights into the mechanism of MAG-mediated signalling.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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