Research progress of bone marrow mesenchymal stem cell transplantation in the treatment of osteoporosis

Abstract

Osteoporosis is defined as a systemic skeletal disease characterised by low bone mass and microarchitectural deterioration of bone tissue, with a consequent increase in bone fragility and susceptibility to fracture. Nowadays more than 200 million individuals are suffering from osteoporosis and still the number of affected people is dramatically increasing due to an aging population and longer life, representing a major public health problem. At present, great progress has been made in the development of drugs for the treatment of osteoporosis, but drug treatment can not reverse bone loss, and will bring a series of toxic and side effects to patients. A large number of studies have shown that homing disorders, osteogenic differentiation and cytokine effect of bone marrow mesenchymal stem cells play an important role in the pathogenesis of osteoporosis. As a new method, transplantation of bone marrow mesenchymal stem cells can not only avoid the side effects of drug therapy, but also fundamentally treat osteoporosis. It has great potential and application value, but there are also many problems to be solved.

Keywords

• osteoporosis
• bone marrow mesenchymal stem cells
• transplant