Nature Communications (Sep 2016)
PKA inhibits WNT signalling in adrenal cortex zonation and prevents malignant tumour development
- Coralie Drelon,
- Annabel Berthon,
- Isabelle Sahut-Barnola,
- Mickaël Mathieu,
- Typhanie Dumontet,
- Stéphanie Rodriguez,
- Marie Batisse-Lignier,
- Houda Tabbal,
- Igor Tauveron,
- Anne-Marie Lefrançois-Martinez,
- Jean-Christophe Pointud,
- Celso E. Gomez-Sanchez,
- Seppo Vainio,
- Jingdong Shan,
- Sonia Sacco,
- Andreas Schedl,
- Constantine A. Stratakis,
- Antoine Martinez,
- Pierre Val
Affiliations
- Coralie Drelon
- CNRS, UMR 6293, GReD, Inserm U1103, Clermont Université
- Annabel Berthon
- CNRS, UMR 6293, GReD, Inserm U1103, Clermont Université
- Isabelle Sahut-Barnola
- CNRS, UMR 6293, GReD, Inserm U1103, Clermont Université
- Mickaël Mathieu
- CNRS, UMR 6293, GReD, Inserm U1103, Clermont Université
- Typhanie Dumontet
- CNRS, UMR 6293, GReD, Inserm U1103, Clermont Université
- Stéphanie Rodriguez
- CNRS, UMR 6293, GReD, Inserm U1103, Clermont Université
- Marie Batisse-Lignier
- CNRS, UMR 6293, GReD, Inserm U1103, Clermont Université
- Houda Tabbal
- CNRS, UMR 6293, GReD, Inserm U1103, Clermont Université
- Igor Tauveron
- CNRS, UMR 6293, GReD, Inserm U1103, Clermont Université
- Anne-Marie Lefrançois-Martinez
- CNRS, UMR 6293, GReD, Inserm U1103, Clermont Université
- Jean-Christophe Pointud
- CNRS, UMR 6293, GReD, Inserm U1103, Clermont Université
- Celso E. Gomez-Sanchez
- Division of Endocrinology, G.V. (Sonny) Montgomery VA Medical Center
- Seppo Vainio
- Biocenter Oulu, Laboratory of Developmental Biology, InfoTech Oulu, Center for cell Matrix Research, Faculty of Biochemistry and Molecular Medicine, University of Oulu
- Jingdong Shan
- Biocenter Oulu, Laboratory of Developmental Biology, InfoTech Oulu, Center for cell Matrix Research, Faculty of Biochemistry and Molecular Medicine, University of Oulu
- Sonia Sacco
- Inserm UMR1091, CNRS UMR 7277, Institute of Biology Valrose
- Andreas Schedl
- Inserm UMR1091, CNRS UMR 7277, Institute of Biology Valrose
- Constantine A. Stratakis
- Developmental Endocrine Oncology and Genetics, Section on Genetics and Endocrinology, Eunice Kennedy Shriver National Institute of Child Health and Human Development
- Antoine Martinez
- CNRS, UMR 6293, GReD, Inserm U1103, Clermont Université
- Pierre Val
- CNRS, UMR 6293, GReD, Inserm U1103, Clermont Université
- DOI
- https://doi.org/10.1038/ncomms12751
- Journal volume & issue
-
Vol. 7,
no. 1
pp. 1 – 14
Abstract
The adrenal cortex undergoes functional zonation to generate an outer zona glomerulosa (ZG) and inner zona fasciculata (ZF), but how this is regulated at a molecular level is unclear. Here, the authors show that ZG differentiation is stimulated by WNT signalling and that PKA blocks WNT signalling to allow ZF differentiation and also prevents WNT-induced cancer development.
