The role of cytoreduction surgery in advanced ovarian cancer (review)

Abstract

The published results of primary and interval debulking surgery in advanced epithelial ovarian cancer are discussed. According to meta-analyses and retrospective studies primary cytoreduction without macroscopic residual tumor has the best results. If the size of the largest residual tumor is more than 1 cm, primary debulking provides no benefit. Published randomized trials didn’t prove benefits of primary debulking surgery.

Keywords

• ovarian cancer
• cytoreductive surgery
• primary debulking surgery
• interval debulking surgery
• optimal cytoreduction
• residual disease
• neoadjuvant chemotherapy