Diabetes, Metabolic Syndrome and Obesity (Nov 2019)

The Role Of Adiponectin, TNF-α And Glutathione In The Pathogenesis And Evolution Of Type 1 Diabetes

  • Szabo CE,
  • Ilieș RF,
  • Aioanei CS,
  • Catana A,
  • Creț V,
  • Șerban RS,
  • Pop IV

Journal volume & issue
Vol. Volume 12
pp. 2303 – 2308

Abstract

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Csilla Enikő Szabo,1,2 Roxana Flavia Ilieș,3 Casian Simon Aioanei,3 Andreea Catana,3 Victoria Creț,2 Radu Sorin Șerban,1,2 Ioan Victor Pop3 1Department of Pediatrics I, Iuliu Hațieganu University of Medicine and Pharmacy, Cluj-Napoca, Romania; 2Pediatric Clinic I, Pediatric Emergency Hospital, Cluj-Napoca, Romania; 3Department of Medical Genetics, Iuliu Hațieganu University of Medicine and Pharmacy, Cluj Napoca, RomaniaCorrespondence: Csilla Enikő SzaboDepartment of Pediatrics I, Iuliu Hațieganu University of Medicine and Pharmacy, Cluj-Napoca, RomaniaEmail [email protected]: Type 1 diabetes (T1DM) is a chronic autoimmune or idiopathic condition, featuring complex and unique interactions between proteins and enzyme systems. The purpose of the present study is to investigate the role of AdipoQ +276G>T, TNF-α-308G>A, GSTT1/GSTM1 polymorphic variants in the development of T1DM.Materials and methods: The study is designed as a cross-sectional study, involving 72 diabetic cases and 90 controls. Genotyping was carried out according to specific protocols for the above-mentioned polymorphic variants.Results: The G allele of AdipoQ was associated with the development of type 1 diabetes (OR 0.577, CI95% 0.336–0.802, p=0.001), similar to the GG and GA genotypes (OR 0.405, CI95% 0.156–0.654, p=0.001 and OR 0.623, CI95% 0.401–0.855, p=0.004). The G allele of TNF-α was marginally associated with the development of type 1 diabetes (OR 0.789, CI95% 0.579–0.956, p=0.005). The presence of the T1 genotype was a strong predictor for type 1 diabetes (OR 3.4, CI95% 1.433–6.243, p<0.001).Conclusion: The results of our study suggest that G alleles of AdipoQ and TNFα act as a protective factor in T1DM, while the T1 allele for GST could be considered a risk factor for the development of Type 1 diabetes in our study group.Keywords: adiponectin, TNF-α, glutathion, pcr-rflp, multiplex, type 1 diabetes

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