Nature Communications (Jun 2018)
A recurrent point mutation in PRKCA is a hallmark of chordoid gliomas
- Shai Rosenberg,
- Iva Simeonova,
- Franck Bielle,
- Maite Verreault,
- Bertille Bance,
- Isabelle Le Roux,
- Mailys Daniau,
- Arun Nadaradjane,
- Vincent Gleize,
- Sophie Paris,
- Yannick Marie,
- Marine Giry,
- Marc Polivka,
- Dominique Figarella-Branger,
- Marie-Hélène Aubriot-Lorton,
- Chiara Villa,
- Alexandre Vasiljevic,
- Emmanuèle Lechapt-Zalcman,
- Michel Kalamarides,
- Ariane Sharif,
- Karima Mokhtari,
- Stefano Maria Pagnotta,
- Antonio Iavarone,
- Anna Lasorella,
- Emmanuelle Huillard,
- Marc Sanson
Affiliations
- Shai Rosenberg
- Inserm U 1127, CNRS UMR 7225, Sorbonne Universités, UPMC Univ Paris 06 UMR S 1127, ICM
- Iva Simeonova
- Inserm U 1127, CNRS UMR 7225, Sorbonne Universités, UPMC Univ Paris 06 UMR S 1127, ICM
- Franck Bielle
- Inserm U 1127, CNRS UMR 7225, Sorbonne Universités, UPMC Univ Paris 06 UMR S 1127, ICM
- Maite Verreault
- Inserm U 1127, CNRS UMR 7225, Sorbonne Universités, UPMC Univ Paris 06 UMR S 1127, ICM
- Bertille Bance
- Inserm U 1127, CNRS UMR 7225, Sorbonne Universités, UPMC Univ Paris 06 UMR S 1127, ICM
- Isabelle Le Roux
- Inserm U 1127, CNRS UMR 7225, Sorbonne Universités, UPMC Univ Paris 06 UMR S 1127, ICM
- Mailys Daniau
- Inserm U 1127, CNRS UMR 7225, Sorbonne Universités, UPMC Univ Paris 06 UMR S 1127, ICM
- Arun Nadaradjane
- Inserm U 1127, CNRS UMR 7225, Sorbonne Universités, UPMC Univ Paris 06 UMR S 1127, ICM
- Vincent Gleize
- Inserm U 1127, CNRS UMR 7225, Sorbonne Universités, UPMC Univ Paris 06 UMR S 1127, ICM
- Sophie Paris
- Inserm U 1127, CNRS UMR 7225, Sorbonne Universités, UPMC Univ Paris 06 UMR S 1127, ICM
- Yannick Marie
- Inserm U 1127, CNRS UMR 7225, Sorbonne Universités, UPMC Univ Paris 06 UMR S 1127, ICM
- Marine Giry
- Inserm U 1127, CNRS UMR 7225, Sorbonne Universités, UPMC Univ Paris 06 UMR S 1127, ICM
- Marc Polivka
- Department of Pathology, AP-HP, Hôpital Lariboisière
- Dominique Figarella-Branger
- Pathology and Neuropathology Department, Assistance Publique-Hôpitaux de Marseille (AP-HM), CHU Timone
- Marie-Hélène Aubriot-Lorton
- Department of Pathology and CRB Ferdinand Cabanne, CHU Dijon Bourgogne
- Chiara Villa
- Department of Pathological Cytology and Anatomy, Foch Hospital
- Alexandre Vasiljevic
- Centre de Biologie et Pathologie Est, Groupement Hospitalier Est, Hospices Civils de Lyon
- Emmanuèle Lechapt-Zalcman
- Department of Pathology, CHU de Caen, Caen, France Normandie Univ, UNICAEN, CEA, CNRS, ISTCT/LDM-TEP Group
- Michel Kalamarides
- Inserm U 1127, CNRS UMR 7225, Sorbonne Universités, UPMC Univ Paris 06 UMR S 1127, ICM
- Ariane Sharif
- INSERM U1172, “Development and Plasticity of the Neuroendocrine Brain”
- Karima Mokhtari
- Inserm U 1127, CNRS UMR 7225, Sorbonne Universités, UPMC Univ Paris 06 UMR S 1127, ICM
- Stefano Maria Pagnotta
- Dipartimento di Scienze e Tecnologie, Università degli Studi del Sannio
- Antonio Iavarone
- Institute for Cancer Genetics, Columbia University Medical Center
- Anna Lasorella
- Institute for Cancer Genetics, Columbia University Medical Center
- Emmanuelle Huillard
- Inserm U 1127, CNRS UMR 7225, Sorbonne Universités, UPMC Univ Paris 06 UMR S 1127, ICM
- Marc Sanson
- Inserm U 1127, CNRS UMR 7225, Sorbonne Universités, UPMC Univ Paris 06 UMR S 1127, ICM
- DOI
- https://doi.org/10.1038/s41467-018-04622-w
- Journal volume & issue
-
Vol. 9,
no. 1
pp. 1 – 9
Abstract
Chordoid glioma is a slow growing diencephalic tumor whose mutational landscape is poorly characterized. Here, the authors perform whole-exome and RNA-sequencing and find that 15 of 16 chordoid glioma cases studied harbor the same PRKCA mutation which results in enhanced proliferation.
