A novel serum spherical lectin from lamprey reveals a more efficient mechanism of immune initiation and regulation in jawless vertebrates

Abstract

Key points A novel serum spherical lectin from lamprey was identified which have agglutination activity against bacteria dependent on calcium. The crystal structure of LSSL was determined, and adhered to both microbial and mammalian glycans with high binding capacity. The role of LSSL was associated with MASP-1 and recruited C3 deposition for pathogen elimination.

Keywords

• Innate immunity
• Lamprey
• LSSL
• Serum