Nature Communications (Oct 2018)

Identification and characterization of a large family of superbinding bacterial SH2 domains

  • Tomonori Kaneko,
  • Peter J. Stogios,
  • Xiang Ruan,
  • Courtney Voss,
  • Elena Evdokimova,
  • Tatiana Skarina,
  • Amy Chung,
  • Xiaoling Liu,
  • Lei Li,
  • Alexei Savchenko,
  • Alexander W. Ensminger,
  • Shawn S.-C. Li

DOI
https://doi.org/10.1038/s41467-018-06943-2
Journal volume & issue
Vol. 9, no. 1
pp. 1 – 15

Abstract

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SH2 domains bind to tyrosine-phosphorylated proteins and play crucial roles in signal transduction in mammalian cells. Here, Kaneko et al. identify a large family of SH2 domains in the bacterial pathogen Legionella that bind to mammalian phosphorylated proteins, in some cases with very high affinity.