Nature Communications (Dec 2018)

ATP-dependent membrane remodeling links EHD1 functions to endocytic recycling

  • Raunaq Deo,
  • Manish S. Kushwah,
  • Sukrut C. Kamerkar,
  • Nagesh Y. Kadam,
  • Srishti Dar,
  • Kavita Babu,
  • Anand Srivastava,
  • Thomas J. Pucadyil

DOI
https://doi.org/10.1038/s41467-018-07586-z
Journal volume & issue
Vol. 9, no. 1
pp. 1 – 15

Abstract

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The GTPase dynamin catalyzes membrane fission but activity of the dynamin-related ATPase EHD1 is unknown. Here, using in vitro reconstitution assays and molecular dynamics simulations, the authors report that EHD1 hydrolyzes ATP to remodel, causing fission of membrane tubes and that this is necessary for endocytic recycling.