S100A6 promotes proliferation and migration of HepG2 cells via increased
               ubiquitin-dependent degradation of p53

Song Dongqiang; Xu Beili; Shi Dongmin; Li Shuyu; Cai Yu

doi:10.1515/med-2020-0101

Open Medicine (Apr 2020)

S100A6 promotes proliferation and migration of HepG2 cells via increased ubiquitin-dependent degradation of p53

Song Dongqiang,
Xu Beili,
Shi Dongmin,
Li Shuyu,
Cai Yu

Affiliations

Song Dongqiang: Liver Cancer Institute, Department of Hepatic Oncology, Zhongshan Hospital of Fudan University,180 Fenglin Road, Xuhui District, Shanghai, P. R. China
Xu Beili: Department of Gastroenterology and Hepatology, Zhongshan Hospital of Fudan University, 180 Fenglin Road, Xuhui District,Shanghai, P. R. China
Shi Dongmin: Liver Cancer Institute, Department of Hepatic Oncology, Zhongshan Hospital of Fudan University,180 Fenglin Road, Xuhui District, Shanghai, P. R. China
Li Shuyu: Department of Gastroenterology and Hepatology, Zhongshan Hospital of Fudan University, 180 Fenglin Road, Xuhui District,Shanghai, P. R. China
Cai Yu: Department of Gastroenterology and Hepatology, Zhongshan Hospital of Fudan University, 180 Fenglin Road, Xuhui District,Shanghai, P. R. China

DOI: https://doi.org/10.1515/med-2020-0101
Journal volume & issue: Vol. 15, no. 1
pp. 317 – 326

Abstract

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S100A6 protein (calcyclin), a small calcium-binding protein of the S100 family, is often upregulated in various types of cancers, including hepatocellular carcinoma (HCC). The aim of this study was to illustrate the molecular mechanism of S100A6 in regulating the proliferation and migration of HCC cells.

Published in Open Medicine

ISSN: 2391-5463 (Online)
Publisher: De Gruyter
Country of publisher: Poland
LCC subjects: Medicine
Website: https://www.degruyter.com/journal/key/med/html

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Abstract

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