Development and testing of a vaccine against infectious atrophic rhinitis and pasteurellosis in pigs

Abstract

This work presents the results of the development and testing of a domestic vaccine against infectious atrophic rhinitis and pasteurellosis in pigs caused by Bordetella bronchiseptica and Pasteurella multocida type A and D. A drug was designed with the following antigenic composition: B. bronchiseptica (strain B-1341) - 6 * 109 m.c. / dose; antigen of P. multocida type A (strain B-1303) - 3 * 109 m.c. / dose; antigen of P. multocida type D (strain B-1308) - 3 * 109 m. c. / dose. A 3% solution of Aluminum hydroxide in a proportion of 10% was used as an adjuvant. One immunizing dose is 2 cm3. In the course of the study, it was found that the survival of piglets obtained from vaccinated sows is 97.16%, which is comparable with the same indicator in the group of animals immunized with the reference drug - 96.96%. Despite the fact that the average weight of piglets in the experimental group on the 45th day of life was 130 g less than of those in the control group, by the 180th day of life, the experimental piglets were 4.33 kg heavier than the animals in the control group. The average daily gain in the experimental group was 33 g more than the one in the control group. Thus, the selected antigenic composition for the inactivated vaccine is optimal, and is capable of providing high immunogenic and protective activity, both in a vivarium and in an industrial pig-breeding enterprise.