Virtual Reality Oculokinetic Perimetry Test Reproducibility and Relationship to Conventional Perimetry and OCT

Jason A. Greenfield, BA; Michael Deiner, PhD; Anwell Nguyen, BA; Gadi Wollstein, MD; Bertil Damato, MD, PhD; Benjamin T. Backus, PhD; Mengfei Wu, MS; Joel S. Schuman, MD; Yvonne Ou, MD

Ophthalmology Science (Mar 2022)

Virtual Reality Oculokinetic Perimetry Test Reproducibility and Relationship to Conventional Perimetry and OCT

Jason A. Greenfield, BA,
Michael Deiner, PhD,
Anwell Nguyen, BA,
Gadi Wollstein, MD,
Bertil Damato, MD, PhD,
Benjamin T. Backus, PhD,
Mengfei Wu, MS,
Joel S. Schuman, MD,
Yvonne Ou, MD

Affiliations

Jason A. Greenfield, BA: Department of Ophthalmology, NYU Langone Health, NYU Grossman School of Medicine, New York, New York
Michael Deiner, PhD: Department of Ophthalmology and Proctor Foundation, University of California, San Francisco, San Francisco, California
Anwell Nguyen, BA: Department of Ophthalmology and Proctor Foundation, University of California, San Francisco, San Francisco, California
Gadi Wollstein, MD: Department of Ophthalmology, NYU Langone Health, NYU Grossman School of Medicine, New York, New York; Department of Biomedical Engineering, NYU Tandon School of Engineering, New York, New York; Department of Neural Science, NYU School of Arts and Sciences, New York, New York
Bertil Damato, MD, PhD: Department of Ophthalmology and Proctor Foundation, University of California, San Francisco, San Francisco, California; Department of Clinical Neurosciences, University of Oxford, Oxford, United Kingdom
Benjamin T. Backus, PhD: Vivid Vision, Inc., San Francisco, California
Mengfei Wu, MS: Department of Ophthalmology, NYU Langone Health, NYU Grossman School of Medicine, New York, New York
Joel S. Schuman, MD: Department of Ophthalmology, NYU Langone Health, NYU Grossman School of Medicine, New York, New York; Department of Biomedical Engineering, NYU Tandon School of Engineering, New York, New York; Department of Neural Science, NYU School of Arts and Sciences, New York, New York; Department of Electrical and Computer Engineering, NYU Tandon School of Engineering, New York, New York; Department of Neuroscience and Physiology, NYU Langone Health, NYU Grossman School of Medicine, New York, New York
Yvonne Ou, MD: Department of Ophthalmology, University of California, San Francisco, San Francisco, California; Correspondence: Yvonne Ou, MD, Department of Ophthalmology, University of California, San Francisco, 10 Koret Way, K141, San Francisco, CA 94143.

Journal volume & issue: Vol. 2, no. 1
p. 100105

Abstract

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Purpose: Vivid Vision Perimetry (VVP; Vivid Vision, Inc) is a novel method for performing in-office and home-based visual field assessment using a virtual reality platform and oculokinetic perimetry. Here we examine the reproducibility of VVP Swift and compare results with conventional standard automated perimetry (SAP) and spectral-domain (SD) OCT. Design: Cross-sectional study. Participants: Fourteen eyes of 7 patients with open-angle glaucoma (OAG) (average age, 64.6 years; 29% women) and 10 eyes of 5 patients with suspected glaucoma (average age, 61.8 years; 40% women) were enrolled. Methods: Patients with OAG and suspected glaucoma were enrolled prospectively and underwent 2 VVP Swift examinations. Results were compared with 1 conventional SAP examination (Humphrey Visual Field [HVF]; Zeiss) and 1 SD OCT examination. Main Outcome Measures: Mean sensitivity (in decibels) obtained for each eye in 2 VVP Swift test sessions and a conventional SAP examination, thickness of the retinal nerve fiber layer (RNFL) and ganglion cell complex (GCC) for the SD OCT examination, and mean test durations of the VVP Swift and SAP examinations. Results: The mean test duration of VVP Swift in both eyes (8.5 minutes) was significantly shorter (P < 0.001) than SAP (12.2 minutes). The average absolute difference of the mean sensitivity between the 2 VVP Swift sessions was found to be 0.73 dB (95% confidence interval [CI], 0.40–1.06). A statistically significant association was found between average mean sensitivity measurements from the VVP and mean deviation (MD) measurements obtained by the HVF with a Pearson correlation coefficient of 0.86 (95% CI, 0.70–0.94; P < 0.001). Mean visual sensitivity measurements from the VVP Swift test were significantly associated with average RNFL thickness (r = 0.66; P = 0.014) and GCC thickness (r = 0.63; P = 0.02), whereas the correlation coefficients between HVF MD and RNFL and GCC were 0.86 (P < 0.001) and 0.83 (P < 0.001), respectively. Conclusions: Our results demonstrated that the VVP Swift test can generate reproducible results and is comparable with conventional SAP. This suggests that the device can be used by clinicians to assess visual function in glaucoma.

Published in Ophthalmology Science

ISSN: 2666-9145 (Online)
Publisher: Elsevier
Country of publisher: United States
LCC subjects: Medicine: Ophthalmology
Website: https://www.journals.elsevier.com/ophthalmology-science/

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