Nature Communications (Nov 2020)

Vascular surveillance by haptotactic blood platelets in inflammation and infection

  • Leo Nicolai,
  • Karin Schiefelbein,
  • Silvia Lipsky,
  • Alexander Leunig,
  • Marie Hoffknecht,
  • Kami Pekayvaz,
  • Ben Raude,
  • Charlotte Marx,
  • Andreas Ehrlich,
  • Joachim Pircher,
  • Zhe Zhang,
  • Inas Saleh,
  • Anna-Kristina Marel,
  • Achim Löf,
  • Tobias Petzold,
  • Michael Lorenz,
  • Konstantin Stark,
  • Robert Pick,
  • Gerhild Rosenberger,
  • Ludwig Weckbach,
  • Bernd Uhl,
  • Sheng Xia,
  • Christoph Andreas Reichel,
  • Barbara Walzog,
  • Christian Schulz,
  • Vanessa Zheden,
  • Markus Bender,
  • Rong Li,
  • Steffen Massberg,
  • Florian Gaertner

DOI
https://doi.org/10.1038/s41467-020-19515-0
Journal volume & issue
Vol. 11, no. 1
pp. 1 – 16

Abstract

Read online

Breakdown of vascular barriers is a major complication of inflammatory diseases. However, the mechanisms underlying platelet recruitment to inflammatory micro-environments remains unclear. Here, the authors identify haptotaxis as a key effector function of immune-responsive platelets