CD4 expression in effector T cells depends on DNA demethylation over a developmentally established stimulus-responsive element

Athmane Teghanemt; Priyanjali Pulipati; Kara Misel-Wuchter; Kenneth Day; Matthew S. Yorek; Ren Yi; Henry L. Keen; Christy Au; Thorsten Maretzky; Prajwal Gurung; Dan R. Littman; Priya D. Issuree

doi:10.1038/s41467-022-28914-4

Nature Communications (Mar 2022)

CD4 expression in effector T cells depends on DNA demethylation over a developmentally established stimulus-responsive element

Athmane Teghanemt,
Priyanjali Pulipati,
Kara Misel-Wuchter,
Kenneth Day,
Matthew S. Yorek,
Ren Yi,
Henry L. Keen,
Christy Au,
Thorsten Maretzky,
Prajwal Gurung,
Dan R. Littman,
Priya D. Issuree

Affiliations

Athmane Teghanemt: Inflammation Program, Roy J. and Lucille A, Carver College of Medicine University of Iowa
Priyanjali Pulipati: Inflammation Program, Roy J. and Lucille A, Carver College of Medicine University of Iowa
Kara Misel-Wuchter: Inflammation Program, Roy J. and Lucille A, Carver College of Medicine University of Iowa
Kenneth Day: Zymo Research Corporation
Matthew S. Yorek: Inflammation Program, Roy J. and Lucille A, Carver College of Medicine University of Iowa
Ren Yi: Department of Computer Science, New York University
Henry L. Keen: Bioinformatics Division of the Iowa Institute of Human Genetics, University of Iowa
Christy Au: The Kimmel Center for Biology and Medicine of the Skirball Institute, New York University School of Medicine
Thorsten Maretzky: Inflammation Program, Roy J. and Lucille A, Carver College of Medicine University of Iowa
Prajwal Gurung: Inflammation Program, Roy J. and Lucille A, Carver College of Medicine University of Iowa
Dan R. Littman: The Kimmel Center for Biology and Medicine of the Skirball Institute, New York University School of Medicine
Priya D. Issuree: Inflammation Program, Roy J. and Lucille A, Carver College of Medicine University of Iowa

DOI: https://doi.org/10.1038/s41467-022-28914-4
Journal volume & issue: Vol. 13, no. 1
pp. 1 – 17

Abstract

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Epigenetic states that are established during thymic T cell development influence functionality of mature T cells. Authors here show that early developmental programming of the Cd4 locus is comprised of DNA-demethylation at a specific stimulus-responsive element, which allows long-term maintenance of activator histone H3K4 trimethylation and transcription.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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