11C-Choline PET/CT and PSA kinetics

Abstract

The potential role of PET/CT with radiolabeled Choline in patients with treated prostate cancer, has not been established yet and no precise indications exist about the use of this emerging modality. According to the literature, the most useful application of Choline PET/CT is represented by the restaging of the disease in case of biochemical relapse for the detection of local and/or, lymph-nodal and/or distant recurrence. Aim of this brief review is to summarize the results of the most relevant published studies with particular interest to a better understanding of the relationship between PSA, PSA kinetics and Choline PET/CT sensitivity and the potential use of PSA kinetics for an optimal selection of the patient population who may benefit the most from this diagnostic procedure especially early after the biochemical recurrence.

Keywords

• Prostatic Neoplasms
• Prostate-Specific Antigen
• Positron-Emission Tomography and Computed Tomography
• Choline
• Neoplasm Recurrence
• Local
• Diagnostic Imaging