Nature Communications (Jun 2020)
An essential role for Argonaute 2 in EGFR-KRAS signaling in pancreatic cancer development
- Sunita Shankar,
- Jean Ching-Yi Tien,
- Ronald F. Siebenaler,
- Seema Chugh,
- Vijaya L. Dommeti,
- Sylvia Zelenka-Wang,
- Xiao-Ming Wang,
- Ingrid J. Apel,
- Jessica Waninger,
- Sanjana Eyunni,
- Alice Xu,
- Malay Mody,
- Andrew Goodrum,
- Yuping Zhang,
- John J. Tesmer,
- Rahul Mannan,
- Xuhong Cao,
- Pankaj Vats,
- Sethuramasundaram Pitchiaya,
- Stephanie J. Ellison,
- Jiaqi Shi,
- Chandan Kumar-Sinha,
- Howard C. Crawford,
- Arul M. Chinnaiyan
Affiliations
- Sunita Shankar
- Michigan Center for Translational Pathology, University of Michigan
- Jean Ching-Yi Tien
- Michigan Center for Translational Pathology, University of Michigan
- Ronald F. Siebenaler
- Michigan Center for Translational Pathology, University of Michigan
- Seema Chugh
- Michigan Center for Translational Pathology, University of Michigan
- Vijaya L. Dommeti
- Michigan Center for Translational Pathology, University of Michigan
- Sylvia Zelenka-Wang
- Michigan Center for Translational Pathology, University of Michigan
- Xiao-Ming Wang
- Michigan Center for Translational Pathology, University of Michigan
- Ingrid J. Apel
- Michigan Center for Translational Pathology, University of Michigan
- Jessica Waninger
- Michigan Center for Translational Pathology, University of Michigan
- Sanjana Eyunni
- Michigan Center for Translational Pathology, University of Michigan
- Alice Xu
- Michigan Center for Translational Pathology, University of Michigan
- Malay Mody
- Michigan Center for Translational Pathology, University of Michigan
- Andrew Goodrum
- Michigan Center for Translational Pathology, University of Michigan
- Yuping Zhang
- Michigan Center for Translational Pathology, University of Michigan
- John J. Tesmer
- Department of Biological Sciences, Purdue University
- Rahul Mannan
- Michigan Center for Translational Pathology, University of Michigan
- Xuhong Cao
- Michigan Center for Translational Pathology, University of Michigan
- Pankaj Vats
- Michigan Center for Translational Pathology, University of Michigan
- Sethuramasundaram Pitchiaya
- Michigan Center for Translational Pathology, University of Michigan
- Stephanie J. Ellison
- Michigan Center for Translational Pathology, University of Michigan
- Jiaqi Shi
- Department of Pathology, University of Michigan
- Chandan Kumar-Sinha
- Michigan Center for Translational Pathology, University of Michigan
- Howard C. Crawford
- Department of Molecular and Integrative Physiology, University of Michigan
- Arul M. Chinnaiyan
- Michigan Center for Translational Pathology, University of Michigan
- DOI
- https://doi.org/10.1038/s41467-020-16309-2
- Journal volume & issue
-
Vol. 11,
no. 1
pp. 1 – 17
Abstract
Argonaute 2 (AGO2) binds RAS and is required for cellular transformation. Here, the authors establish a KRAS-driven mouse model of pancreatic cancer with conditional loss of AGO2 and show that the early phase of neoplastic lesion initiation is dependent on EGFR/RAS but not AGO2, while AGO2 is required for pancreatic ductal adenocarcinoma progression and metastasis.
