A Rare Variant of Germ Cell Ovarian Tumour with Glandular Differentiation and Cutaneous Metastasis

Abstract

A 35-year-old lady presented with a large ovarian tumour with cutaneous metastasis and tumour markers suggestive of germ cell tumour. Earlier, she underwent laparotomy for suspected chronic ectopic pregnancy of which details were unavailable. Her tissue biopsy from tumour as well as cutaneous deposit showed adenocarcinoma. She was confirmed to have a rare variant of glandular differentiation of germ cell tumour. In view of inoperable masses, Bleomycin Etoposide Cisplatin (BEP) chemotherapy was initiated and tumour along with cutaneous metastasis showed features of regression after two cycles. However, patient died due to complications, following chemotherapy. Glandular differentiation of germ cell tumour must be kept in mind if histopathology shows adenocarcinoma in presence of elevated α Fetoprotein (α-FP), β-HCG, LDH. Cutaneous metastasis in ovarian malignancy carries a poor prognosis.

Keywords

• adenocarcinoma
• atypical histopathology
• elevated tumour markers