Enantioselective synthesis of N-alkylindoles enabled by nickel-catalyzed C-C coupling

Lun Li; Jiangtao Ren; Jingjie Zhou; Xiaomei Wu; Zhihui Shao; Xiaodong Yang; Deyun Qian

doi:10.1038/s41467-022-34615-9

Nature Communications (Nov 2022)

Enantioselective synthesis of N-alkylindoles enabled by nickel-catalyzed C-C coupling

Lun Li,
Jiangtao Ren,
Jingjie Zhou,
Xiaomei Wu,
Zhihui Shao,
Xiaodong Yang,
Deyun Qian

Affiliations

Lun Li: Key Laboratory of Medicinal Chemistry for Natural Resource, Ministry of Education, School of Chemical Science and Technology, Yunnan Provincial Center for Research & Development of Natural Products, and State Key Laboratory for Conservation and Utilization of Bio-Resources in Yunnan, Yunnan University
Jiangtao Ren: Key Laboratory of Medicinal Chemistry for Natural Resource, Ministry of Education, School of Chemical Science and Technology, Yunnan Provincial Center for Research & Development of Natural Products, and State Key Laboratory for Conservation and Utilization of Bio-Resources in Yunnan, Yunnan University
Jingjie Zhou: Key Laboratory of Medicinal Chemistry for Natural Resource, Ministry of Education, School of Chemical Science and Technology, Yunnan Provincial Center for Research & Development of Natural Products, and State Key Laboratory for Conservation and Utilization of Bio-Resources in Yunnan, Yunnan University
Xiaomei Wu: Key Laboratory of Medicinal Chemistry for Natural Resource, Ministry of Education, School of Chemical Science and Technology, Yunnan Provincial Center for Research & Development of Natural Products, and State Key Laboratory for Conservation and Utilization of Bio-Resources in Yunnan, Yunnan University
Zhihui Shao: Key Laboratory of Medicinal Chemistry for Natural Resource, Ministry of Education, School of Chemical Science and Technology, Yunnan Provincial Center for Research & Development of Natural Products, and State Key Laboratory for Conservation and Utilization of Bio-Resources in Yunnan, Yunnan University
Xiaodong Yang: Key Laboratory of Medicinal Chemistry for Natural Resource, Ministry of Education, School of Chemical Science and Technology, Yunnan Provincial Center for Research & Development of Natural Products, and State Key Laboratory for Conservation and Utilization of Bio-Resources in Yunnan, Yunnan University
Deyun Qian: Key Laboratory of Medicinal Chemistry for Natural Resource, Ministry of Education, School of Chemical Science and Technology, Yunnan Provincial Center for Research & Development of Natural Products, and State Key Laboratory for Conservation and Utilization of Bio-Resources in Yunnan, Yunnan University

DOI: https://doi.org/10.1038/s41467-022-34615-9
Journal volume & issue: Vol. 13, no. 1
pp. 1 – 10

Abstract

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Enantioenriched N-alkylindole compounds, in which nitrogen is bound to a stereogenic sp3 carbon, are target molecules in the fields of biological, medicinal, and organic chemistry. Here the authors show a nickel-catalyzed C-C coupling protocol to synthesize these molecules from N-indolylsubstituted alkenes.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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