Nature Communications (Nov 2022)
Enantioselective synthesis of N-alkylindoles enabled by nickel-catalyzed C-C coupling
Abstract
Enantioenriched N-alkylindole compounds, in which nitrogen is bound to a stereogenic sp3 carbon, are target molecules in the fields of biological, medicinal, and organic chemistry. Here the authors show a nickel-catalyzed C-C coupling protocol to synthesize these molecules from N-indolylsubstituted alkenes.