Frontiers in Public Health (Dec 2022)

Time above range for predicting the development of type 2 diabetes

  • Alejandra Marco,
  • Alejandra Marco,
  • Marcos Pazos-Couselo,
  • Marcos Pazos-Couselo,
  • Jesús Moreno-Fernandez,
  • Ana Díez-Fernández,
  • Manuela Alonso-Sampedro,
  • Manuela Alonso-Sampedro,
  • Carmen Fernández-Merino,
  • Carmen Fernández-Merino,
  • Arturo Gonzalez-Quintela,
  • Arturo Gonzalez-Quintela,
  • Francisco Gude,
  • Francisco Gude,
  • Francisco Gude

DOI
https://doi.org/10.3389/fpubh.2022.1005513
Journal volume & issue
Vol. 10

Abstract

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AimTo investigate the prognostic value of time range metrics, as measured by continuous glucose monitoring, with respect to the development of type 2 diabetes (T2D).Research design and methodsA total of 499 persons without diabetes from the general population were followed-up for 5 years. Time range metrics were measured at the start and medical records were checked over the period study.ResultsTwenty-two subjects (8.3 per 1,000 person-years) developed T2D. After adjusting for age, gender, family history of diabetes, body mass index and glycated hemoglobin concentration, multivariate analysis revealed 'time above range' (TAR, i.e., with a plasma glucose concentration of >140 mg/dL) to be significantly associated with a greater risk (OR = 1.06, CI 1.01–1.11) of developing diabetes (AUC = 0.94, Brier = 0.035).ConclusionsTime above range provides additional information to that offered by glycated hemoglobin to identify patients at a higher risk of developing type 2 diabetes in a population-based study.

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