Indian Heart Journal (May 2019)

The Gene Polymorphism of Angiotensin-Converting Enzyme Intron Deletion and Angiotensin-Converting Enzyme G2350A in Patients With Left Ventricular Hypertrophy: A Meta-analysis

  • Jonny Karunia Fajar,
  • Budi Susetio Pikir,
  • Erdo Puncak Sidarta,
  • Putu Nina Berlinda Saka,
  • Rizal Rahmanda Akbar,
  • Teuku Heriansyah

Journal volume & issue
Vol. 71, no. 3
pp. 199 – 206

Abstract

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Objectives: The aim of the study was to evaluate the correlation between left ventricular hypertrophy and the gene polymorphism of angiotensin-converting enzyme (ACE) intron deletion (I/D) and ACE G2350A. Methods: Information related to the sample size and genotype frequencies was extracted from each study. Results: Our results found that the D allele (p = 0.0180) and DD genotype (p = 0.0110) of ACE I/D had a significant association with increasing the risk of left ventricular hypertrophy, whereas the I allele (p = 0.0180), but not II (p = 0.1660) and ID genotypes (p = 0.1430), was associated with decreasing the risk of left ventricular hypertrophy. On other hand, we found that the A allele (p = 0.0020) and GA genotype of ACE G2350A (p = 0.0070) had the correlation with increasing the risk of left ventricular hypertrophy. Conclusions: Our meta-analysis reveals that the D allele of ACE I/D and the A allele of ACE G2350A are associated with increasing the risk of left ventricular hypertrophy. Keywords: Left ventricular hypertrophy, Angiotensin-converting enzyme, ACE I/D, ACE G2350A