Human Vaccines & Immunotherapeutics (Mar 2021)

Neutralizing antibody response elicited by SARS-CoV-2 receptor-binding domain

  • Ping-Han Huang,
  • Hsiao-Han Tsai,
  • Bo-Hung Liao,
  • Yi-Ling Lin,
  • Jia-Tsrong Jan,
  • Mi-Hua Tao,
  • Yu-Chi Chou,
  • Che-Ming Jack Hu,
  • Hui-Wen Chen

DOI
https://doi.org/10.1080/21645515.2020.1814098
Journal volume & issue
Vol. 17, no. 3
pp. 654 – 655

Abstract

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A safe and effective vaccine candidate is urgently needed for the ongoing COVID-19 pandemic, caused by SARS-CoV-2. Here we report that recombinant SARS-CoV-2 RBD protein immunization in mice is able to elicit a strong antibody response and potent neutralizing capability as measured using live or pseudotyped SARS-CoV-2 neutralization assays.

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