Human Vaccines & Immunotherapeutics (Mar 2021)
Neutralizing antibody response elicited by SARS-CoV-2 receptor-binding domain
Abstract
A safe and effective vaccine candidate is urgently needed for the ongoing COVID-19 pandemic, caused by SARS-CoV-2. Here we report that recombinant SARS-CoV-2 RBD protein immunization in mice is able to elicit a strong antibody response and potent neutralizing capability as measured using live or pseudotyped SARS-CoV-2 neutralization assays.
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