Nature Communications (May 2021)
Sox9 and Rbpj differentially regulate endothelial to mesenchymal transition and wound scarring in murine endovascular progenitors
- Jilai Zhao,
- Jatin Patel,
- Simranpreet Kaur,
- Seen-Ling Sim,
- Ho Yi Wong,
- Cassandra Styke,
- Isabella Hogan,
- Sam Kahler,
- Hamish Hamilton,
- Racheal Wadlow,
- James Dight,
- Ghazaleh Hashemi,
- Laura Sormani,
- Edwige Roy,
- Mervin C. Yoder,
- Mathias Francois,
- Kiarash Khosrotehrani
Affiliations
- Jilai Zhao
- The University of Queensland Diamantina Institute, The University of Queensland
- Jatin Patel
- The University of Queensland Diamantina Institute, The University of Queensland
- Simranpreet Kaur
- The University of Queensland Diamantina Institute, The University of Queensland
- Seen-Ling Sim
- The University of Queensland Diamantina Institute, The University of Queensland
- Ho Yi Wong
- The University of Queensland Diamantina Institute, The University of Queensland
- Cassandra Styke
- The University of Queensland Diamantina Institute, The University of Queensland
- Isabella Hogan
- The University of Queensland Diamantina Institute, The University of Queensland
- Sam Kahler
- The University of Queensland Diamantina Institute, The University of Queensland
- Hamish Hamilton
- The University of Queensland Diamantina Institute, The University of Queensland
- Racheal Wadlow
- The University of Queensland Diamantina Institute, The University of Queensland
- James Dight
- The University of Queensland Diamantina Institute, The University of Queensland
- Ghazaleh Hashemi
- The University of Queensland Diamantina Institute, The University of Queensland
- Laura Sormani
- The University of Queensland Diamantina Institute, The University of Queensland
- Edwige Roy
- The University of Queensland Diamantina Institute, The University of Queensland
- Mervin C. Yoder
- Indiana Center for Regenerative Medicine and Engineering
- Mathias Francois
- The David Richmond Laboratory for Cardiovascular Development: Gene Regulation and Editing Program, The Centenary Institute
- Kiarash Khosrotehrani
- The University of Queensland Diamantina Institute, The University of Queensland
- DOI
- https://doi.org/10.1038/s41467-021-22717-9
- Journal volume & issue
-
Vol. 12,
no. 1
pp. 1 – 17
Abstract
How endothelial to mesenchymal transition is regulated in endovascular progenitors is unclear. Here, the authors show that blocking Sox9 expression in murine endovascular progenitors regulates this transition on skin wounding, affecting the size of scarring, with changes in Rbpj having the opposite effect.
