Nature Communications (Jul 2016)

Functional characterization of the 12p12.1 renal cancer-susceptibility locus implicates BHLHE41

  • Pierre Bigot,
  • Leandro M. Colli,
  • Mitchell J. Machiela,
  • Lea Jessop,
  • Timothy A. Myers,
  • Julie Carrouget,
  • Sarah Wagner,
  • David Roberson,
  • Caroline Eymerit,
  • Daniel Henrion,
  • Stephen J. Chanock

DOI
https://doi.org/10.1038/ncomms12098
Journal volume & issue
Vol. 7, no. 1
pp. 1 – 10

Abstract

Read online

A common susceptibility haplotype for renal cell carcinoma is located on chromosome 12p12.1. Here, the authors show that the variant rs7132434 alters binding of the AP-1 transcription factor, which increases the expression of BHLHE41in renal cells.