Frontiers in Molecular Neuroscience (Sep 2019)
Pavlovian Olfactory Fear Conditioning: Its Neural Circuity and Importance for Understanding Clinical Fear-Based Disorders
- Marziah Hakim,
- Marziah Hakim,
- Marziah Hakim,
- Andrew R. Battle,
- Andrew R. Battle,
- Andrew R. Battle,
- Andrew R. Battle,
- Arnauld Belmer,
- Arnauld Belmer,
- Selena E. Bartlett,
- Selena E. Bartlett,
- Selena E. Bartlett,
- Luke R. Johnson,
- Luke R. Johnson,
- Luke R. Johnson,
- Luke R. Johnson,
- Fatemeh Chehrehasa,
- Fatemeh Chehrehasa,
- Fatemeh Chehrehasa,
- Fatemeh Chehrehasa
Affiliations
- Marziah Hakim
- School of Biomedical Science, Queensland University of Technology, Brisbane, QLD, Australia
- Marziah Hakim
- Institute of Health and Biomedical Innovation, Queensland University of Technology, Kelvin Grove, QLD, Australia
- Marziah Hakim
- Mater Medical Research Institute and Queensland Health, Queensland University of Technology, The University of Queensland, Woolloongabba, QLD, Australia
- Andrew R. Battle
- School of Biomedical Science, Queensland University of Technology, Brisbane, QLD, Australia
- Andrew R. Battle
- Institute of Health and Biomedical Innovation, Queensland University of Technology, Kelvin Grove, QLD, Australia
- Andrew R. Battle
- Mater Medical Research Institute and Queensland Health, Queensland University of Technology, The University of Queensland, Woolloongabba, QLD, Australia
- Andrew R. Battle
- The University of Queensland Diamantina Institute, Translational Research Institute, Woolloongabba, QLD, Australia
- Arnauld Belmer
- Institute of Health and Biomedical Innovation, Queensland University of Technology, Kelvin Grove, QLD, Australia
- Arnauld Belmer
- Mater Medical Research Institute and Queensland Health, Queensland University of Technology, The University of Queensland, Woolloongabba, QLD, Australia
- Selena E. Bartlett
- Institute of Health and Biomedical Innovation, Queensland University of Technology, Kelvin Grove, QLD, Australia
- Selena E. Bartlett
- Mater Medical Research Institute and Queensland Health, Queensland University of Technology, The University of Queensland, Woolloongabba, QLD, Australia
- Selena E. Bartlett
- School of Clinical Sciences, Queensland University of Technology, Brisbane, QLD, Australia
- Luke R. Johnson
- School of Biomedical Science, Queensland University of Technology, Brisbane, QLD, Australia
- Luke R. Johnson
- Mater Medical Research Institute and Queensland Health, Queensland University of Technology, The University of Queensland, Woolloongabba, QLD, Australia
- Luke R. Johnson
- Division of Psychology, School of Medicine, University of Tasmania, Launceston, TAS, Australia
- Luke R. Johnson
- Center for the Study of Traumatic Stress, School of Medicine, College of Health and Medicine, Uniformed Services University, Bethesda, MD, United States
- Fatemeh Chehrehasa
- School of Biomedical Science, Queensland University of Technology, Brisbane, QLD, Australia
- Fatemeh Chehrehasa
- Institute of Health and Biomedical Innovation, Queensland University of Technology, Kelvin Grove, QLD, Australia
- Fatemeh Chehrehasa
- Mater Medical Research Institute and Queensland Health, Queensland University of Technology, The University of Queensland, Woolloongabba, QLD, Australia
- Fatemeh Chehrehasa
- Clem Jones Centre for Neurobiology and Stem Cell Research, Griffith Institute for Drug Discovery, Griffith University, Nathan, QLD, Australia
- DOI
- https://doi.org/10.3389/fnmol.2019.00221
- Journal volume & issue
-
Vol. 12
Abstract
Odors have proven to be the most resilient trigger for memories of high emotional saliency. Fear associated olfactory memories pose a detrimental threat of potentially transforming into severe mental illness such as fear and anxiety-related disorders. Many studies have deliberated on auditory, visual and general contextual fear memory (CFC) processes; however, fewer studies have investigated mechanisms of olfactory fear memory. Evidence strongly suggests that the neuroanatomical representation of olfactory fear memory differs from that of auditory and visual fear memory. The aim of this review article is to revisit the literature regarding the understanding of the neurobiological process of fear conditioning and to illustrate the circuitry of olfactory fear memory.
Keywords