A giant amphipathic helix from a perilipin that is adapted for coating lipid droplets

Alenka Čopič; Sandra Antoine-Bally; Manuel Giménez-Andrés; César La Torre Garay; Bruno Antonny; Marco M. Manni; Sophie Pagnotta; Jeanne Guihot; Catherine L. Jackson

doi:10.1038/s41467-018-03717-8

Nature Communications (Apr 2018)

A giant amphipathic helix from a perilipin that is adapted for coating lipid droplets

Alenka Čopič,
Sandra Antoine-Bally,
Manuel Giménez-Andrés,
César La Torre Garay,
Bruno Antonny,
Marco M. Manni,
Sophie Pagnotta,
Jeanne Guihot,
Catherine L. Jackson

Affiliations

Alenka Čopič: Institut Jacques Monod, CNRS, UMR 7592, Université Paris Diderot, Sorbonne Paris Cité
Sandra Antoine-Bally: Institut Jacques Monod, CNRS, UMR 7592, Université Paris Diderot, Sorbonne Paris Cité
Manuel Giménez-Andrés: Institut Jacques Monod, CNRS, UMR 7592, Université Paris Diderot, Sorbonne Paris Cité
César La Torre Garay: Institut Jacques Monod, CNRS, UMR 7592, Université Paris Diderot, Sorbonne Paris Cité
Bruno Antonny: Université Côte d’Azur, CNRS, IPMC
Marco M. Manni: Université Côte d’Azur, CNRS, IPMC
Sophie Pagnotta: Université Côte d’Azur, CNRS, IPMC
Jeanne Guihot: Institut Jacques Monod, CNRS, UMR 7592, Université Paris Diderot, Sorbonne Paris Cité
Catherine L. Jackson: Institut Jacques Monod, CNRS, UMR 7592, Université Paris Diderot, Sorbonne Paris Cité

DOI: https://doi.org/10.1038/s41467-018-03717-8
Journal volume & issue: Vol. 9, no. 1
pp. 1 – 16

Abstract

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Lipid droplets are cellular organelles important for cellular homeostasis and their disruption has been implicated in many diseases. Here the authors use a large amphipathic helix from perilipin 4 to uncover parameters important for specific lipid droplet targeting and stabilization of the oil core.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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