The rise of genetically engineered mouse models of pancreatitis: A review of literature

Abstract

Pancreatitis is increasingly recognized as not merely a local inflammation of the pancreas but also a disease with high frequency of systemic sequelae. Current understanding of the cellular mechanisms that trigger it and affect the development of sequelae are limited. Genetically engineered mouse models can be a useful tool to study the pathophysiology of pancreatitis. This article gives an overview of the genetically engineered mouse models that spontaneously develop pancreatitis and discusses those that most closely replicate different pancreatitis hallmarks observed in humans.

Keywords

• genetically engineered mouse models
• pancreatitis
• inflammation
• autophagy
• endoplasmic
• reticulum stress