Response of H. Pylori Eradication Treatment in Patients with Normal and Below Normal Serum Vitamin D Levels

Abstract

OBJECTIVE: To determine the response of H. pylori eradication treatment in patients with normal and below normal serum vitamin D levels at medical wards of Liaquat University Hospital, Jamshoro. METHODOLOGY: This retrospective, self-funded study includes data from 100 patients from March - September 2019. Patient with H. Pylori gastritis were included and exclusion criteria was use of Proton Pump Inhibitors or Vitamin D supplements, and H. Pylori eradication therapy in the past 2 months. H. Pylori was confirmed on serology and stool antigen. Patients were given triple regime eradication therapy and then treatment response was observed by stool antigen. Vitamin D levels were tested and participants divided into Sufficient and Deficient groups. The data was then gathered on a predesigned proforma and analyzed using SPSS version 20.0. RESULTS: Total 55% patients were female and 45% were male and belongs to 18 to 60 years of age. The eradication was successful in 62% and unsuccessful in 38%. The mean vitamin D level was lower in the eradication failure population compared to the eradication successful population (12.6±4.31 vs 32.75±6.63; P<0.01). Amongst the treatment failure group, 78.9% (30) of patients were deficient in vitamin D, as compared to 12.4% (20) of patients being vitamin D deficient in treatment successful group. CONCLUSION: Our results demonstrated that vitamin D deficiency is a factor associated with eradication failure of H. pylori infection.

Keywords

• helicobacter pylori
• serology
• stool antigen
• eradication therapy
• vitamin d.