Integrative analysis of genomic and transcriptomic characteristics associated with progression of aggressive thyroid cancer

Seong-Keun Yoo; Young Shin Song; Eun Kyung Lee; Jinha Hwang; Hwan Hee Kim; Gyeongseo Jung; Young A Kim; Su-jin Kim; Sun Wook Cho; Jae-Kyung Won; Eun-Jae Chung; Jong-Yeon Shin; Kyu Eun Lee; Jong-Il Kim; Young Joo Park; Jeong-Sun Seo

doi:10.1038/s41467-019-10680-5

Nature Communications (Jun 2019)

Integrative analysis of genomic and transcriptomic characteristics associated with progression of aggressive thyroid cancer

Seong-Keun Yoo,
Young Shin Song,
Eun Kyung Lee,
Jinha Hwang,
Hwan Hee Kim,
Gyeongseo Jung,
Young A Kim,
Su-jin Kim,
Sun Wook Cho,
Jae-Kyung Won,
Eun-Jae Chung,
Jong-Yeon Shin,
Kyu Eun Lee,
Jong-Il Kim,
Young Joo Park,
Jeong-Sun Seo

Affiliations

Seong-Keun Yoo: Genomic Medicine Institute, Medical Research Center, Seoul National University
Young Shin Song: Department of Internal Medicine, Seoul National University College of Medicine
Eun Kyung Lee: Center for Thyroid Cancer, National Cancer Center
Jinha Hwang: Department of Biomedical Sciences, Seoul National University Graduate School
Hwan Hee Kim: Department of Internal Medicine, Seoul National University College of Medicine
Gyeongseo Jung: Department of Internal Medicine, Seoul National University College of Medicine
Young A Kim: Department of Pathology, Seoul National University Boramae Medical Center
Su-jin Kim: Department of Surgery, Seoul National University College of Medicine
Sun Wook Cho: Department of Internal Medicine, Seoul National University College of Medicine
Jae-Kyung Won: Department of Pathology, Seoul National University College of Medicine
Eun-Jae Chung: Department of Otorhinolaryngology-Head and Neck Surgery, Seoul National University College of Medicine
Jong-Yeon Shin: Genomic Medicine Institute, Medical Research Center, Seoul National University
Kyu Eun Lee: Genomic Medicine Institute, Medical Research Center, Seoul National University
Jong-Il Kim: Genomic Medicine Institute, Medical Research Center, Seoul National University
Young Joo Park: Genomic Medicine Institute, Medical Research Center, Seoul National University
Jeong-Sun Seo: Genomic Medicine Institute, Medical Research Center, Seoul National University

DOI: https://doi.org/10.1038/s41467-019-10680-5
Journal volume & issue: Vol. 10, no. 1
pp. 1 – 12

Abstract

Read online

Anaplastic thyroid cancer (ATC) and advanced differentiated thyroid cancers (DTCs) come with a dismal prognosis. Here, Yoo and colleagues reveal the genomic and transcriptomic landscape of ATC and DTC, highlighting potential therapeutic vulnerabilities.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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