Frontiers in Pharmacology (Sep 2023)

Baricitinib treatment for refractory skin changes in POEMS syndrome: a case report

  • Jingjing Xie,
  • Jingjing Xie,
  • Zhiling Li,
  • Yubao Jiang,
  • Yubao Jiang,
  • Dabin Tang,
  • Dabin Tang,
  • Xia Qiu,
  • Xia Qiu,
  • Ertao Jia,
  • Ertao Jia,
  • Jianyong Zhang,
  • Jianyong Zhang

DOI
https://doi.org/10.3389/fphar.2023.1191158
Journal volume & issue
Vol. 14

Abstract

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Polyneuropathy, organomegaly, endocrinopathy, monoclonal plasma cell disorder, and skin changes (POEMS) syndrome is a multisystem disorder that has limited treatment options. Here, we described a case of a 55-year-old female subject who was treated for multiple drugs, but the skin symptoms continued to progress; the patient responded well to baricitinib. This suggests that JAK/STAT signaling pathways play an essential role in the pathological process of POEMS syndrome.

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