Lineage-specific protection and immune imprinting shape the age distributions of influenza B cases

Marcos C. Vieira; Celeste M. Donato; Philip Arevalo; Guus F. Rimmelzwaan; Timothy Wood; Liza Lopez; Q. Sue Huang; Vijaykrishna Dhanasekaran; Katia Koelle; Sarah Cobey

doi:10.1038/s41467-021-24566-y

Nature Communications (Jul 2021)

Lineage-specific protection and immune imprinting shape the age distributions of influenza B cases

Marcos C. Vieira,
Celeste M. Donato,
Philip Arevalo,
Guus F. Rimmelzwaan,
Timothy Wood,
Liza Lopez,
Q. Sue Huang,
Vijaykrishna Dhanasekaran,
Katia Koelle,
Sarah Cobey

Affiliations

Marcos C. Vieira: Department of Ecology and Evolution, University of Chicago
Celeste M. Donato: Enteric Diseases Group, Murdoch Children’s Research Institute
Philip Arevalo: Department of Ecology and Evolution, University of Chicago
Guus F. Rimmelzwaan: Research Center for Emerging Infections and Zoonoses, University of Veterinary Medicine Hannover
Timothy Wood: Institute of Environmental Science and Research
Liza Lopez: Institute of Environmental Science and Research
Q. Sue Huang: Institute of Environmental Science and Research
Vijaykrishna Dhanasekaran: Department of Microbiology, Biomedicine Discovery Institute, Monash University
Katia Koelle: Department of Biology, Emory University
Sarah Cobey: Department of Ecology and Evolution, University of Chicago

DOI: https://doi.org/10.1038/s41467-021-24566-y
Journal volume & issue: Vol. 12, no. 1
pp. 1 – 14

Abstract

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The earliest infections with influenza A shape the immune responses to future infections, but it is not known if this phenomenon applies to influenza B. Here, the authors use influenza B case data from New Zealand and find evidence for both lineage-specific and imprinting protection.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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