Detection of Biochemically Recurrent Prostate Cancer with [<sup>18</sup>F]DCFPyL PET/CT: An Updated Systematic Review and Meta-Analysis with a Focus on Correlations with Serum Prostate-Specific Antigen Parameters

Mohammad S. Sadaghiani; Sara Sheikhbahaei; Abdullah Al-Zaghal; Lilja B. Solnes; Martin G. Pomper; Jorge D. Oldan; Gary A. Ulaner; Michael A. Gorin; Steven P. Rowe

doi:10.3390/tomography9040120

Tomography (Aug 2023)

Detection of Biochemically Recurrent Prostate Cancer with [<sup>18</sup>F]DCFPyL PET/CT: An Updated Systematic Review and Meta-Analysis with a Focus on Correlations with Serum Prostate-Specific Antigen Parameters

Mohammad S. Sadaghiani,
Sara Sheikhbahaei,
Abdullah Al-Zaghal,
Lilja B. Solnes,
Martin G. Pomper,
Jorge D. Oldan,
Gary A. Ulaner,
Michael A. Gorin,
Steven P. Rowe

Affiliations

Mohammad S. Sadaghiani: The Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA
Sara Sheikhbahaei: The Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA
Abdullah Al-Zaghal: The Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA
Lilja B. Solnes: The Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA
Martin G. Pomper: The Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA
Jorge D. Oldan: Department of Radiology, University of North Carolina, Chapel Hill, NC 27599, USA
Gary A. Ulaner: Molecular Imaging and Therapy, Hoag Family Cancer Institute, Irvine, CA 92633, USA
Michael A. Gorin: Milton and Carroll Petrie Department of Urology, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA
Steven P. Rowe: Department of Radiology, University of North Carolina, Chapel Hill, NC 27599, USA

DOI: https://doi.org/10.3390/tomography9040120
Journal volume & issue: Vol. 9, no. 4
pp. 1504 – 1514

Abstract

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[18F]DCFPyL is increasingly used for prostate-specific membrane antigen (PSMA) mediated imaging of men with biochemically recurrent prostate cancer (BRPCa). In this meta-analysis, which is updated with the addition of multiple new studies, including the definitive phase III CONDOR trial, we discuss the detection efficiency of [18F]DCFPyL in BRPCa patients. PubMed was searched on 29 September 2022. Studies evaluating the diagnostic performance of [18F]DCFPyL among patients with BRPCa were included. The overall pooled detection rate with a 95% confidence interval (95% CI) was calculated among all included studies and stratified among patients with PSA ≥ 2 vs. 18F]DCFPyL in men with BRPCa has trended down since a previous meta-analysis, which may reflect increasingly stringent inclusion criteria for studies over time.

Published in Tomography

ISSN: 2379-1381 (Print); 2379-139X (Online)
Publisher: MDPI AG
Country of publisher: Switzerland
LCC subjects: Medicine: Medicine (General): Computer applications to medicine. Medical informatics
Website: https://www.mdpi.com/journal/tomography

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Abstract

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