Nature Communications (Aug 2020)

Histone methyltransferase DOT1L coordinates AR and MYC stability in prostate cancer

  • R. Vatapalli,
  • V. Sagar,
  • Y. Rodriguez,
  • J. C. Zhao,
  • K. Unno,
  • S. Pamarthy,
  • B. Lysy,
  • J. Anker,
  • H. Han,
  • Y. A. Yoo,
  • M. Truica,
  • Z. R. Chalmers,
  • F. Giles,
  • J. Yu,
  • D. Chakravarti,
  • B. Carneiro,
  • S. A. Abdulkadir

DOI
https://doi.org/10.1038/s41467-020-18013-7
Journal volume & issue
Vol. 11, no. 1
pp. 1 – 15

Abstract

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Histone methyltransferase, DOTL1 is implicated in the pathogenesis of MLL-rearranged leukemia, however, not much is known of its role in prostate cancer (PCa). Here, the authors report that DOTL1 inhibition suppresses both androgen receptor and MYC pathways in a negative feed forward manner to reduce growth of AR-positive PCa.