Nature Communications (Feb 2020)

Mechanical properties measured by atomic force microscopy define health biomarkers in ageing C. elegans

  • Clara L. Essmann,
  • Daniel Martinez-Martinez,
  • Rosina Pryor,
  • Kit-Yi Leung,
  • Kalaivani Bala Krishnan,
  • Prudence Pokway Lui,
  • Nicholas D. E. Greene,
  • André E. X. Brown,
  • Vijay M. Pawar,
  • Mandayam A. Srinivasan,
  • Filipe Cabreiro

DOI
https://doi.org/10.1038/s41467-020-14785-0
Journal volume & issue
Vol. 11, no. 1
pp. 1 – 16

Abstract

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The development of reliable measures of health in ageing organisms is a need in ageing research. Using atomic force microscopy, here, the authors assess whole body stiffness of worms and show that it reflects organismal fitness.