Frontiers in Plant Science (Apr 2023)

Alternative splicing: transcriptional regulatory network in agroforestry

  • Syed Sarfaraz Hussain,
  • Syed Sarfaraz Hussain,
  • Manzar Abbas,
  • Sammar Abbas,
  • Mingke Wei,
  • Ahmed H. El-Sappah,
  • Ahmed H. El-Sappah,
  • Yuhan Sun,
  • Yun Li,
  • Arthur J. Ragauskas,
  • Arthur J. Ragauskas,
  • Arthur J. Ragauskas,
  • Quanzi Li

DOI
https://doi.org/10.3389/fpls.2023.1158965
Journal volume & issue
Vol. 14

Abstract

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Alternative splicing (AS) in plants plays a key role in regulating the expression of numerous transcripts from a single gene in a regulatory pathway. Variable concentrations of growth regulatory hormones and external stimuli trigger alternative splicing to switch among different growth stages and adapt to environmental stresses. In the AS phenomenon, a spliceosome causes differential transcriptional modifications in messenger RNA (mRNAs), resulting in partial or complete retention of one or more introns as compared to fully spliced mRNA. Differentially expressed proteins translated from intron-retaining messenger RNA (mRNAir) perform vital functions in the feedback mechanism. At the post-transcriptional level, AS causes the remodeling of transcription factors (TFs) by the addition or deletion of binding domains to activate and/or repress transcription. In this study, we have summarized the specific role of AS in the regulation of gene expression through repression and activation of the transcriptional regulatory network under external stimuli and switch among developmental stages.

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