Orally Administered Activated Charcoal as a Medical Countermeasure for Acute Radiation Syndrome in Rats

Elisaveta Snezhkova; Natalia Rodionova; Dennis Bilko; Joaquin Silvestre-Albero; Alexey Sydorenko; Olga Yurchenko; Marharyta Pakharenko; Mo Alavijeh; Kvitoslava Bardakhivska; Natalia Riabchenko; Vladimir Nikolaev

doi:10.3390/app11073174

Applied Sciences (Apr 2021)

Orally Administered Activated Charcoal as a Medical Countermeasure for Acute Radiation Syndrome in Rats

Elisaveta Snezhkova,
Natalia Rodionova,
Dennis Bilko,
Joaquin Silvestre-Albero,
Alexey Sydorenko,
Olga Yurchenko,
Marharyta Pakharenko,
Mo Alavijeh,
Kvitoslava Bardakhivska,
Natalia Riabchenko,
Vladimir Nikolaev

Affiliations

Elisaveta Snezhkova: Department of Means & Methods of Adsorptive Therapy, R. E. Kavetsky Institute of Experimental Pathology, Oncology and Radiobiology, National Academy of Sciences of Ukraine, 03022 Kyiv, Ukraine
Natalia Rodionova: Department of Radiobiology and Radioecology, Institute for Nuclear Research of National Academy of Sciences of Ukraine, 02000 Kyiv, Ukraine
Dennis Bilko: Center of Molecular and Cell Research, National University of Kyiv-Mohyla Academy, 04070 Kyiv, Ukraine
Joaquin Silvestre-Albero: Laboratorio de Materiales Avanzados, Departamento de Química Inorgánica-Instituto Universitario de Materiales, Universidad de Alicante, E-03690 San Vicente del Raspeig, Spain
Alexey Sydorenko: Department of Means & Methods of Adsorptive Therapy, R. E. Kavetsky Institute of Experimental Pathology, Oncology and Radiobiology, National Academy of Sciences of Ukraine, 03022 Kyiv, Ukraine
Olga Yurchenko: Department of Means & Methods of Adsorptive Therapy, R. E. Kavetsky Institute of Experimental Pathology, Oncology and Radiobiology, National Academy of Sciences of Ukraine, 03022 Kyiv, Ukraine
Marharyta Pakharenko: Center of Molecular and Cell Research, National University of Kyiv-Mohyla Academy, 04070 Kyiv, Ukraine
Mo Alavijeh: Pharmidex Pharmaceutical Services Ltd., London EC2V 8AU, UK
Kvitoslava Bardakhivska: Department of Means & Methods of Adsorptive Therapy, R. E. Kavetsky Institute of Experimental Pathology, Oncology and Radiobiology, National Academy of Sciences of Ukraine, 03022 Kyiv, Ukraine
Natalia Riabchenko: Department of Radiobiology and Radioecology, Institute for Nuclear Research of National Academy of Sciences of Ukraine, 02000 Kyiv, Ukraine
Vladimir Nikolaev: Department of Means & Methods of Adsorptive Therapy, R. E. Kavetsky Institute of Experimental Pathology, Oncology and Radiobiology, National Academy of Sciences of Ukraine, 03022 Kyiv, Ukraine

DOI: https://doi.org/10.3390/app11073174
Journal volume & issue: Vol. 11, no. 7
p. 3174

Abstract

Read online

Activated charcoal (AC) can be taken orally as enterosorbent for treatment of pathological states related to exogenous and endogenous intoxications. Synthesized granulated AC with a highly developed active surface (SBET ~2700 m2/g) was used as a medical countermeasure (MCM) to acute radiation sickness (ARS) in rats after total body X-ray irradiation. AC demonstrates positive results in ARS treatment, as expressed in, (i) a decrease in body weight loss, (ii) a protection of bone marrow (BM) cells colony formation capacity, (iii) a reduction of BM chromosomal aberrations and small intestine and spleen tissue damage, (iv) an amelioration of white blood cell count, and (v) a mitigation of superoxide ion generation rate in the liver. AC oral prescription seems to be perspective modality of ARS treatment.

Published in Applied Sciences

ISSN: 2076-3417 (Online)
Publisher: MDPI AG
Country of publisher: Switzerland
LCC subjects: Technology: Engineering (General). Civil engineering (General); Science: Biology (General); Science: Physics; Science: Chemistry
Website: http://www.mdpi.com/journal/applsci

About the journal

Abstract

Keywords