Frontiers in Cardiovascular Medicine (Jan 2023)
One-year outcomes in cardiogenic shock triggered by ventricular arrhythmia: An analysis of the FRENSHOCK multicenter prospective registry
- Miloud Cherbi,
- Miloud Cherbi,
- François Roubille,
- Nicolas Lamblin,
- Laurent Bonello,
- Laurent Bonello,
- Laurent Bonello,
- Guillaume Leurent,
- Bruno Levy,
- Meyer Elbaz,
- Meyer Elbaz,
- Sebastien Champion,
- Pascal Lim,
- Pascal Lim,
- Francis Schneider,
- Alain Cariou,
- Hadi Khachab,
- Jeremy Bourenne,
- Marie-France Seronde,
- Guillaume Schurtz,
- Brahim Harbaoui,
- Brahim Harbaoui,
- Gerald Vanzetto,
- Charlotte Quentin,
- Xavier Delabranche,
- Nadia Aissaoui,
- Nicolas Combaret,
- Danka Tomasevic,
- Benjamin Marchandot,
- Benoit Lattuca,
- Patrick Henry,
- Edouard Gerbaud,
- Edouard Gerbaud,
- Eric Bonnefoy,
- Etienne Puymirat,
- Etienne Puymirat,
- Philippe Maury,
- Philippe Maury,
- Clément Delmas,
- Clément Delmas,
- Clément Delmas
Affiliations
- Miloud Cherbi
- Intensive Cardiac Care Unit, Rangueil University Hospital, Toulouse, France
- Miloud Cherbi
- Institute of Metabolic and Cardiovascular Diseases (I2MC), UMR-1048, National Institute of Health and Medical Research (INSERM), Toulouse, France
- François Roubille
- PhyMedExp, Université de Montpellier, INSERM, CNRS, Cardiology Department, INI-CRT, CHU de Montpellier, Montpellier, France
- Nicolas Lamblin
- Department of Cardiology, Urgences et Soins Intensifs de Cardiologie, CHU Lille, University of Lille, Inserm U1167, Lille, France
- Laurent Bonello
- Aix-Marseille Université, Marseille, France
- Laurent Bonello
- Intensive Care Unit, Department of Cardiology, Assistance Publique-Hôpitaux de Marseille, Hôpital Nord, Marseille, France
- Laurent Bonello
- Mediterranean Association for Research and Studies in Cardiology (MARS Cardio), Marseille, France
- Guillaume Leurent
- Department of Cardiology, CHU Rennes, Inserm, LTSI-UMR 1099, Univ Rennes 1, Rennes, France
- Bruno Levy
- CHRU Nancy, Réanimation Médicale Brabois, Nancy, France
- Meyer Elbaz
- Intensive Cardiac Care Unit, Rangueil University Hospital, Toulouse, France
- Meyer Elbaz
- Institute of Metabolic and Cardiovascular Diseases (I2MC), UMR-1048, National Institute of Health and Medical Research (INSERM), Toulouse, France
- Sebastien Champion
- 0Clinique de Parly 2, Ramsay Générale de Santé, Le Chesnay, France
- Pascal Lim
- 1Université Paris Est-Créteil, INSERM, IMRB, Créteil, France
- Pascal Lim
- 2AP-HP, Hôpital Universitaire Henri-Mondor, Service de Cardiologie, Créteil, France
- Francis Schneider
- 3Médecine Intensive-Réanimation, Hôpital de Hautepierre, Hôpitaux Universitaires de Strasbourg, Strasbourg, France
- Alain Cariou
- 4Medical Intensive Care Unit, Cochin Hospital, Assistance Publique-Hôpitaux de Paris, Centre–Université de Paris, Medical School, Paris, France
- Hadi Khachab
- 5Intensive Cardiac Care Unit, Department of Cardiology, CH d’Aix-en-Provence, Aix-en-Provence, France
- Jeremy Bourenne
- 6Aix-Marseille Université, Service de Réanimation des Urgences, CHU La Timone 2, Marseille, France
- Marie-France Seronde
- 7Servicede Cardiologie CHU Besançon, Besançon, France
- Guillaume Schurtz
- Department of Cardiology, Urgences et Soins Intensifs de Cardiologie, CHU Lille, University of Lille, Inserm U1167, Lille, France
- Brahim Harbaoui
- 8Cardiology Department, Hôpital Croix-Rousse and Hôpital Lyon Sud, Hospices Civils de Lyon, Lyon, France
- Brahim Harbaoui
- 9Department of Cardiology, University of Lyon, CREATIS UMR5220, INSERM U1044, INSA-15, Lyon, France
- Gerald Vanzetto
- 0Department of Cardiology, Hôpital de Grenoble, Grenoble, France
- Charlotte Quentin
- 1Service de Réanimation Polyvalente, Centre Hospitalier Broussais, 1 Rue de la Marne, Saint-Malo, France
- Xavier Delabranche
- 2Réanimation Chirurgicale Polyvalente, Pôle Anesthésie–Réanimation Chirurgicale–Médecine Péri-opératoire, Les Hôpitaux Universitaires de Strasbourg, Nouvel Hôpital Civil 1, Porte de l’Hôpital, Strasbourg, France
- Nadia Aissaoui
- 5Intensive Cardiac Care Unit, Department of Cardiology, CH d’Aix-en-Provence, Aix-en-Provence, France
- Nicolas Combaret
- 3Department of Cardiology, CHU Clermont-Ferrand, CNRS, Université Clermont Auvergne, Clermont-Ferrand, France
- Danka Tomasevic
- 4Intensive Cardiac Care Unit, Lyon Brom University Hospital, Lyon, France
- Benjamin Marchandot
- 5Université de Strasbourg, Pôle d’Activité Médico-Chirurgicale Cardio-Vasculaire, Nouvel Hôpital Civil, Centre Hospitalier Universitaire, Strasbourg, France
- Benoit Lattuca
- 6Department of Cardiology, Nîmes University Hospital, University of Montpellier, Nîmes, France
- Patrick Henry
- 7Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Lariboisière, Department of Cardiology, Paris, France
- Edouard Gerbaud
- 8Intensive Cardiac Care Unit and Interventional Cardiology, Hôpital Cardiologique du Haut Lévêque, Pessac, France
- Edouard Gerbaud
- 9Bordeaux Cardio-Thoracic Research Centre, U1045, Bordeaux University, Hôpital Xavier Arnozan, Pessac, France
- Eric Bonnefoy
- 4Intensive Cardiac Care Unit, Lyon Brom University Hospital, Lyon, France
- Etienne Puymirat
- 0Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Européen Georges Pompidou, Department of Cardiology, Paris, France
- Etienne Puymirat
- 1Université de Paris, Paris, France
- Philippe Maury
- Intensive Cardiac Care Unit, Rangueil University Hospital, Toulouse, France
- Philippe Maury
- Institute of Metabolic and Cardiovascular Diseases (I2MC), UMR-1048, National Institute of Health and Medical Research (INSERM), Toulouse, France
- Clément Delmas
- Intensive Cardiac Care Unit, Rangueil University Hospital, Toulouse, France
- Clément Delmas
- Institute of Metabolic and Cardiovascular Diseases (I2MC), UMR-1048, National Institute of Health and Medical Research (INSERM), Toulouse, France
- Clément Delmas
- 2REICATRA, Institut Saint Jacques, CHU de Toulouse, Toulouse, France
- DOI
- https://doi.org/10.3389/fcvm.2023.1092904
- Journal volume & issue
-
Vol. 10
Abstract
BackgroundCardiogenic shock (CS) is a life-threatening condition carrying poor prognosis, potentially triggered by ventricular arrhythmia (VA). Whether the occurrence of VA as trigger of CS worsens the prognosis compared to non-VA triggers remains unclear. The aim of this study was to evaluate 1-year outcomes [mortality, heart transplantation, ventricular assist devices (VAD)] between VA-triggered and non-VA-triggered CS.MethodsFRENSHOCK is a prospective multicenter registry including 772 CS patients from 49 centers. One to three triggers can be identified in the registry (ischemic, mechanical complications, ventricular/supraventricular arrhythmia, bradycardia, iatrogenesis, infection, non-compliance). Baseline characteristics, management and 1-year outcomes were analyzed according to the VA-trigger in the CS population.ResultsWithin 769 CS patients included, 94 were VA-triggered (12.2%) and were compared to others. At 1 year, although there was no mortality difference [42.6 vs. 45.3%, HR 0.94 (0.67–1.30), p = 0.7], VA-triggered CS resulted in more heart transplantations and VAD (17 vs. 9%, p = 0.02). Into VA-triggered CS group, though there was no 1-year mortality difference between ischemic and non-ischemic cardiomyopathies [42.5 vs. 42.6%, HR 0.97 (0.52–1.81), p = 0.92], non-ischemic cardiomyopathy led to more heart transplantations and VAD (25.9 vs. 5%, p = 0.02).ConclusionVA-triggered CS did not show higher mortality compared to other triggers but resulted in more heart transplantation and VAD at 1 year, especially in non-ischemic cardiomyopathy, suggesting the need for earlier evaluation by advanced heart failure specialized team for a possible indication of mechanical circulatory support or heart transplantation.Clinical trial registrationhttps://clinicaltrials.gov, identifier NCT02703038.
Keywords