Gastroprotective effects of extract of Jasminum grandiflorum L. flower in HCl/EtOH-induced gastric mucosal ulceration mice

Yizi Zhang; Lingli Sun; Xingfei Lai; Xingjia Peng; Shuai Wen; Zhenbiao Zhang; Yinzheng Xie; Qiuhua Li; Ruohong Chen; Xi Zheng; Kun Zhang; Shili Sun; Dongli Li

Biomedicine & Pharmacotherapy (Dec 2021)

Gastroprotective effects of extract of Jasminum grandiflorum L. flower in HCl/EtOH-induced gastric mucosal ulceration mice

Yizi Zhang,
Lingli Sun,
Xingfei Lai,
Xingjia Peng,
Shuai Wen,
Zhenbiao Zhang,
Yinzheng Xie,
Qiuhua Li,
Ruohong Chen,
Xi Zheng,
Kun Zhang,
Shili Sun,
Dongli Li

Affiliations

Yizi Zhang: School of Biotechnology and Health Sciences, Wuyi University, Jiangmen 529020, China
Lingli Sun: Tea Research Institute, Guangdong Academy of Agricultural Sciences / Guangdong Key Laboratory of Tea Resources Innovation & Utilization, Guangzhou 510640, China
Xingfei Lai: Tea Research Institute, Guangdong Academy of Agricultural Sciences / Guangdong Key Laboratory of Tea Resources Innovation & Utilization, Guangzhou 510640, China
Xingjia Peng: School of Biotechnology and Health Sciences, Wuyi University, Jiangmen 529020, China
Shuai Wen: Tea Research Institute, Guangdong Academy of Agricultural Sciences / Guangdong Key Laboratory of Tea Resources Innovation & Utilization, Guangzhou 510640, China
Zhenbiao Zhang: Tea Research Institute, Guangdong Academy of Agricultural Sciences / Guangdong Key Laboratory of Tea Resources Innovation & Utilization, Guangzhou 510640, China
Yinzheng Xie: School of Biotechnology and Health Sciences, Wuyi University, Jiangmen 529020, China
Qiuhua Li: Tea Research Institute, Guangdong Academy of Agricultural Sciences / Guangdong Key Laboratory of Tea Resources Innovation & Utilization, Guangzhou 510640, China
Ruohong Chen: Tea Research Institute, Guangdong Academy of Agricultural Sciences / Guangdong Key Laboratory of Tea Resources Innovation & Utilization, Guangzhou 510640, China
Xi Zheng: School of Biotechnology and Health Sciences, Wuyi University, Jiangmen 529020, China
Kun Zhang: School of Biotechnology and Health Sciences, Wuyi University, Jiangmen 529020, China
Shili Sun: Tea Research Institute, Guangdong Academy of Agricultural Sciences / Guangdong Key Laboratory of Tea Resources Innovation & Utilization, Guangzhou 510640, China; Corresponding author.
Dongli Li: School of Biotechnology and Health Sciences, Wuyi University, Jiangmen 529020, China; International Healthcare Innovation Institute (Jiangmen), Jiangmen 529040, China; Corresponding author at: School of Biotechnology and Health Sciences, Wuyi University, Jiangmen 529020, China.

Journal volume & issue: Vol. 144
p. 112268

Abstract

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Jasminum grandiflorum L. is a medicinal plant used to treat hepatitis and gastritis, but the mechanisms underlying its protective effects against gastrointestinal mucosal damage remain to be elucidated. In this study, we analyzed the effects of four different extracts and two compounds from the flower of J. grandiflorum in a mouse model of HCl/EtOH-induced gastric ulcer. The flower extracts alleviated gastric mucosal ulceration by increasing PGE2 production and the activity of antioxidant enzymes, along with the suppression of reactive oxygen species (ROS) generation, lipid peroxidation, apoptosis-related proteins, pro-inflammatory cytokines and nitric oxide (NO) production.

Published in Biomedicine & Pharmacotherapy

ISSN: 0753-3322 (Print); 1950-6007 (Online)
Publisher: Elsevier
Country of publisher: France
LCC subjects: Medicine: Therapeutics. Pharmacology
Website: https://www.journals.elsevier.com/biomedicine-and-pharmacotherapy

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