?-Fluoro-Benzylphosphonates as Reagents for the Preparation of 1-Fluoro-1-Aryl Alkenes and ?-Fluorostilbenes

Abstract

The preparation of several fluoro-benzylphosphonates Ar-CHF-PO(OEt)2 and their Wadsworth-Emmons type olefination with aldehydes and ketones are described affording fluorostyrenes and fluorostilbenes. Some of these compounds are incorporated into target molecules tested as drug candidates.

Keywords

• Fluoro-benzylphosphonates
• Fluoroolefins
• Horner-wadsworth-emmons olefination