Bone density of defects treated with lyophilized amniotic membrane versus colagen membrane: a tomographic and histomorfogenic study in a rabbi´s femur.

Abstract

The aim of this study was to compare the bone density of bone defects treated with lyophilizated amniotic membrane (LAM) and collagen Membrane (CM), at 3 and 5 weeks. Two bone defects of 4mm in diameter and 6mm deep were created in left distal femoral diaphysis of New Zealand rabbits (n=12). The animals were randomly divided into 2 groups. One of the defects was covered with lyophilized amniotic membrane (Rosa Chambergo Tissue Bank/National Institute of Child Health-IPEN, Lima, Peru) or collagen Membrane (Dentium Co, Seoul, Korea). The second was left uncovered (NC). The rabbits were killed after 3 and 5 weeks (3 rabbits/period). The results showed a high bone density and repair of the defect by new bone. The tomographic study revealed that the bone density of the defects treated with LAM at 3 weeks was equivalent to the density obtained with CM and higher density compared with NC (p0.05). The results show that lyophilizated amniotic membrane provides bone density equal or higher to the collagen membrane.

Keywords

• amniotic membrane dressings
• bone regeneration
• Cone-Beam
• Dental Implant
• biological dressing.