Nature Communications (Jul 2020)

Molecular determinants for dsDNA translocation by the transcription-repair coupling and evolvability factor Mfd

  • Christiane Brugger,
  • Cheng Zhang,
  • Margaret M. Suhanovsky,
  • David D. Kim,
  • Amy N. Sinclair,
  • Dmitry Lyumkis,
  • Alexandra M. Deaconescu

DOI
https://doi.org/10.1038/s41467-020-17457-1
Journal volume & issue
Vol. 11, no. 1
pp. 1 – 12

Abstract

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Transcription-repair coupling factors (TRCFs) are large ATPases that mediate the preferential repair of the transcribed DNA strand. Here the authors reveal the cryo-EM structure of DNA-bound Mfd, the bacterial TRCF, and provide molecular insights into its mode of action.