5-PGDH expression in breast cancer cells

Abstract

This paper analyzes 15-PGDH gene expression in the human breast cancer (BC) cell liness and describes the molecular principles through which the expression of the enzyme 15-PGDH is controlled in the tumor cells with a varying metastatic potential. There is an inverse correla- tion of 15-PGDH gene expression with COX-2 expression and the metastatic potential of tumor cells. Investigation of mechanisms for 15-PGDH regulation opens up new vistas and possibilities for the design of effective drugs for the targeted therapy of metastatic forms of BC.

Keywords

• breast cancer
• cox-1
• cox-2
• 15-pgdh
• predictive marker for breast cancer
• cox-2 inhibitors
• pge2
• mcf-7
• bt-474
• and zr-75-1 human breast tumor cell lines
• targeted therapy goal