Regulated degradation of HMG CoA reductase requires conformational changes in sterol-sensing domain

Hongwen Chen; Xiaofeng Qi; Rebecca A. Faulkner; Marc M. Schumacher; Linda M. Donnelly; Russell A. DeBose-Boyd; Xiaochun Li

doi:10.1038/s41467-022-32025-5

Nature Communications (Jul 2022)

Regulated degradation of HMG CoA reductase requires conformational changes in sterol-sensing domain

Hongwen Chen,
Xiaofeng Qi,
Rebecca A. Faulkner,
Marc M. Schumacher,
Linda M. Donnelly,
Russell A. DeBose-Boyd,
Xiaochun Li

Affiliations

Hongwen Chen: Department of Molecular Genetics, University of Texas Southwestern Medical Center
Xiaofeng Qi: Department of Molecular Genetics, University of Texas Southwestern Medical Center
Rebecca A. Faulkner: Department of Molecular Genetics, University of Texas Southwestern Medical Center
Marc M. Schumacher: Department of Molecular Genetics, University of Texas Southwestern Medical Center
Linda M. Donnelly: Department of Molecular Genetics, University of Texas Southwestern Medical Center
Russell A. DeBose-Boyd: Department of Molecular Genetics, University of Texas Southwestern Medical Center
Xiaochun Li: Department of Molecular Genetics, University of Texas Southwestern Medical Center

DOI: https://doi.org/10.1038/s41467-022-32025-5
Journal volume & issue: Vol. 13, no. 1
pp. 1 – 12

Abstract

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HMG-CoA reductase (HMGCR) is regulated by UBIAD1 and Insigs and initializes cholesterol synthesis. Here authors show that the sterol sensing domain of HMGCR undergoes conformational changes to regulate its degradation via binding its protein modulators.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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